Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.

Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.

The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity.

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Main Authors: QUINTAO, C. C. R., CAMARGO, L. S. de A., BRANDAO, H. de M., SARAIVA, N. Z., MUNK, M.
Other Authors: CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; HUMBERTO DE MELLO BRANDAO, CNPGL; NAIARA ZOCCAL SARAIVA, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora.
Format: Artigo de periódico biblioteca
Language:Ingles
English
Published: 2022-05-10
Subjects:Nanoestrutura, Nanotubo de carbono, Genetically modified, Nanotecnologia, Ácido Nucléico, Melhoramento Genético Animal, Genética Animal, Nucleic acids, Embryonic structures, Nanotubes,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/1142832
https://doi.org/10.31744/einstein_journal/2022RB5898
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spelling dig-alice-doc-11428322022-05-10T16:12:50Z Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice. QUINTAO, C. C. R. CAMARGO, L. S. de A. BRANDAO, H. de M. SARAIVA, N. Z. MUNK, M. CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; HUMBERTO DE MELLO BRANDAO, CNPGL; NAIARA ZOCCAL SARAIVA, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. Nanoestrutura Nanotubo de carbono Genetically modified Nanotecnologia Ácido Nucléico Melhoramento Genético Animal Genética Animal Nucleic acids Embryonic structures Nanotubes The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity. 2022-05-10T16:12:42Z 2022-05-10T16:12:42Z 2022-05-10 2022 Artigo de periódico Einstein, v. 20, eRB5898, 2022. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1142832 https://doi.org/10.31744/einstein_journal/2022RB5898 Ingles en openAccess
institution EMBRAPA
collection DSpace
country Brasil
countrycode BR
component Bibliográfico
access En linea
databasecode dig-alice
tag biblioteca
region America del Sur
libraryname Sistema de bibliotecas de EMBRAPA
language Ingles
English
topic Nanoestrutura
Nanotubo de carbono
Genetically modified
Nanotecnologia
Ácido Nucléico
Melhoramento Genético Animal
Genética Animal
Nucleic acids
Embryonic structures
Nanotubes
Nanoestrutura
Nanotubo de carbono
Genetically modified
Nanotecnologia
Ácido Nucléico
Melhoramento Genético Animal
Genética Animal
Nucleic acids
Embryonic structures
Nanotubes
spellingShingle Nanoestrutura
Nanotubo de carbono
Genetically modified
Nanotecnologia
Ácido Nucléico
Melhoramento Genético Animal
Genética Animal
Nucleic acids
Embryonic structures
Nanotubes
Nanoestrutura
Nanotubo de carbono
Genetically modified
Nanotecnologia
Ácido Nucléico
Melhoramento Genético Animal
Genética Animal
Nucleic acids
Embryonic structures
Nanotubes
QUINTAO, C. C. R.
CAMARGO, L. S. de A.
BRANDAO, H. de M.
SARAIVA, N. Z.
MUNK, M.
Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
description The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity.
author2 CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; HUMBERTO DE MELLO BRANDAO, CNPGL; NAIARA ZOCCAL SARAIVA, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora.
author_facet CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; HUMBERTO DE MELLO BRANDAO, CNPGL; NAIARA ZOCCAL SARAIVA, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora.
QUINTAO, C. C. R.
CAMARGO, L. S. de A.
BRANDAO, H. de M.
SARAIVA, N. Z.
MUNK, M.
format Artigo de periódico
topic_facet Nanoestrutura
Nanotubo de carbono
Genetically modified
Nanotecnologia
Ácido Nucléico
Melhoramento Genético Animal
Genética Animal
Nucleic acids
Embryonic structures
Nanotubes
author QUINTAO, C. C. R.
CAMARGO, L. S. de A.
BRANDAO, H. de M.
SARAIVA, N. Z.
MUNK, M.
author_sort QUINTAO, C. C. R.
title Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
title_short Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
title_full Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
title_fullStr Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
title_full_unstemmed Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
title_sort challenges in the use of nanostructures as carriers of nucleic acids in clinical practice.
publishDate 2022-05-10
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1142832
https://doi.org/10.31744/einstein_journal/2022RB5898
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AT saraivanz challengesintheuseofnanostructuresascarriersofnucleicacidsinclinicalpractice
AT munkm challengesintheuseofnanostructuresascarriersofnucleicacidsinclinicalpractice
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