Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

PETRÔNIO, M. S.; BARROS-ALEXANDRINO, T. T.; LIMA, A. M. F.; ASSIS, O. B. G.; INOUE-NAGATA, A. K.; NAKASU, E. Y. T.; TIERA, M. J.; PILON, L.; MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH.

Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.

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Main Authors:	PETRÔNIO, M. S., BARROS-ALEXANDRINO, T. T., LIMA, A. M. F., ASSIS, O. B. G., INOUE-NAGATA, A. K., NAKASU, E. Y. T., TIERA, M. J., PILON, L.
Other Authors:	MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH.
Format:	Artigo de periódico biblioteca
Language:	Ingles English
Published:	2021-11-18
Subjects:	Tomato mosaic virus, Double-stranded RNA, Lettuce, RNA interference,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285 https://doi.org/10.33263/BRIAC124.52665279
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id	dig-alice-doc-1136285
record_format	koha
spelling	dig-alice-doc-11362852021-11-18T15:01:22Z Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation. PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L. MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH. Tomato mosaic virus Double-stranded RNA Lettuce RNA interference Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops. 2021-11-18T15:01:13Z 2021-11-18T15:01:13Z 2021-11-18 2022 Artigo de periódico Biointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022. 2069-5837 http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285 https://doi.org/10.33263/BRIAC124.52665279 Ingles en openAccess
institution	EMBRAPA
collection	DSpace
country	Brasil
countrycode	BR
component	Bibliográfico
access	En linea
databasecode	dig-alice
tag	biblioteca
region	America del Sur
libraryname	Sistema de bibliotecas de EMBRAPA
language	Ingles English
topic	Tomato mosaic virus Double-stranded RNA Lettuce RNA interference Tomato mosaic virus Double-stranded RNA Lettuce RNA interference
spellingShingle	Tomato mosaic virus Double-stranded RNA Lettuce RNA interference Tomato mosaic virus Double-stranded RNA Lettuce RNA interference PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L. Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
description	Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.
author2	MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH.
author_facet	MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH. PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L.
format	Artigo de periódico
topic_facet	Tomato mosaic virus Double-stranded RNA Lettuce RNA interference
author	PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L.
author_sort	PETRÔNIO, M. S.
title	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_short	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_full	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_fullStr	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_full_unstemmed	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_sort	physicochemical and toxicity investigation of chitosan-based dsrna nanocarrier formation.
publishDate	2021-11-18
url	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285 https://doi.org/10.33263/BRIAC124.52665279
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Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

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