Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

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Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.

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Bibliographic Details
Main Authors: PETRÔNIO, M. S., BARROS-ALEXANDRINO, T. T., LIMA, A. M. F., ASSIS, O. B. G., INOUE-NAGATA, A. K., NAKASU, E. Y. T., TIERA, M. J., PILON, L.
Other Authors: MAICON S. PETRÔNIO, UNESP; TAIS T. BARROS-ALEXANDRINO; ALINE M. F. LIMA, UNESP; ODILIO B. G. ASSIS; ALICE KAZUKO INOUE NAGATA, CNPH; ERICH YUKIO TEMPEL NAKASU, CNPH; MARCIO J. TIERA, UNESP; LUCIMEIRE PILON, CNPH.
Format: Artigo de periódico biblioteca
Language:Ingles
English
Published: 2021-11-18
Subjects:Tomato mosaic virus, Double-stranded RNA, Lettuce, RNA interference,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285
https://doi.org/10.33263/BRIAC124.52665279
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Summary:Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.

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