Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.

DUARTE, D. S.; NAASCIMENTO, J. A. de A.; BRITTO, D. de; Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA.

Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.

Given the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed spherical structures and the release profile was similar for all reactional volumes. Thus, the system is suitable for scale-up for NP production.

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Bibliographic Details
Main Authors:	DUARTE, D. S., NAASCIMENTO, J. A. de A., BRITTO, D. de
Other Authors:	Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA.
Format:	Artigo de periódico biblioteca
Language:	Ingles English
Published:	2020-07-16
Subjects:	Polifenóis, Quitosana, Nanopartículas, Agroindustria, Encapsulamento, Vitamina C, Subproduto, Vitamin content, Polyphenols, Byproducts,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123889 http://dx.doi.org/10.1590/1413-7054201943023819
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spelling	dig-alice-doc-11238892020-07-17T11:11:28Z Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles. DUARTE, D. S. NAASCIMENTO, J. A. de A. BRITTO, D. de Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA. Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts Given the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed spherical structures and the release profile was similar for all reactional volumes. Thus, the system is suitable for scale-up for NP production. 2020-07-17T11:11:21Z 2020-07-17T11:11:21Z 2020-07-16 2019 Artigo de periódico Ciência e Agrotecnologia, v. 43, e023819, 2019. 1981-1829 http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123889 http://dx.doi.org/10.1590/1413-7054201943023819 Ingles en openAccess
institution	EMBRAPA
collection	DSpace
country	Brasil
countrycode	BR
component	Bibliográfico
access	En linea
databasecode	dig-alice
tag	biblioteca
region	America del Sur
libraryname	Sistema de bibliotecas de EMBRAPA
language	Ingles English
topic	Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts
spellingShingle	Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts DUARTE, D. S. NAASCIMENTO, J. A. de A. BRITTO, D. de Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
description	Given the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed spherical structures and the release profile was similar for all reactional volumes. Thus, the system is suitable for scale-up for NP production.
author2	Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA.
author_facet	Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA. DUARTE, D. S. NAASCIMENTO, J. A. de A. BRITTO, D. de
format	Artigo de periódico
topic_facet	Polifenóis Quitosana Nanopartículas Agroindustria Encapsulamento Vitamina C Subproduto Vitamin content Polyphenols Byproducts
author	DUARTE, D. S. NAASCIMENTO, J. A. de A. BRITTO, D. de
author_sort	DUARTE, D. S.
title	Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
title_short	Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
title_full	Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
title_fullStr	Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
title_full_unstemmed	Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
title_sort	scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.
publishDate	2020-07-16
url	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123889 http://dx.doi.org/10.1590/1413-7054201943023819
work_keys_str_mv	AT duarteds scaleupinthesynthesisofnanoparticlesforencapsulationofagroindustrialactiveprinciples AT naascimentojadea scaleupinthesynthesisofnanoparticlesforencapsulationofagroindustrialactiveprinciples AT brittodde scaleupinthesynthesisofnanoparticlesforencapsulationofagroindustrialactiveprinciples
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Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.

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