Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle.
Positively correlated with carcass weight and animal growth, the ribeye area (REA) and the backfat thickness (BFT) are economic important carcass traits, which impact directly on producer's payment. The selection of these traits has not been satisfactory since they are expressed later in the animal's life and multigene regulated. So, next-generation technologies have been applied in this area to improve animal's selection and better understand the molecular mechanisms involved in the development of these traits. Correlation network analysis, performed by tools like WGCNA (Weighted Correlation Network Analysis), has been used to explore gene-gene interactions and gene-phenotype correlations. Thus, this study aimed to identify putative candidate genes and metabolic pathways that regulate REA and BFT by constructing a gene co-expression network using WGCNA and RNA sequencing data, to better understand genetic and molecular variations behind these complex traits in Nelore cattle.
Main Authors: | , , , , , , |
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Format: | Artigo de periódico biblioteca |
Language: | English eng |
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2019-02-15
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Subjects: | Functional enrichment analysis, RNA-Seq data, WGCNA, Ribeye area, Gordura Animal, Gado Nelore, Carcaça, Backfat, Thickness, Beef carcasses, |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106063 |
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dig-alice-doc-11060632019-02-15T23:47:12Z Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. VIGNATO B. S. COUTINHO, L. L. POLETI, M. D. CESAR, A. S. M. MONCAU, C. T. REGITANO, L. C. de A. BALIEIRO, J. C. C. Bárbara Silva-Vignato, USP; Luiz L. Coutinho, USP; Mirele D. Poleti, USP; Aline S. M. Cesar, USP; Cristina T. Moncau, Universidade Federal de Lavras; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Júlio C. C. Balieiro, USP. Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses Positively correlated with carcass weight and animal growth, the ribeye area (REA) and the backfat thickness (BFT) are economic important carcass traits, which impact directly on producer's payment. The selection of these traits has not been satisfactory since they are expressed later in the animal's life and multigene regulated. So, next-generation technologies have been applied in this area to improve animal's selection and better understand the molecular mechanisms involved in the development of these traits. Correlation network analysis, performed by tools like WGCNA (Weighted Correlation Network Analysis), has been used to explore gene-gene interactions and gene-phenotype correlations. Thus, this study aimed to identify putative candidate genes and metabolic pathways that regulate REA and BFT by constructing a gene co-expression network using WGCNA and RNA sequencing data, to better understand genetic and molecular variations behind these complex traits in Nelore cattle. 2019-02-15T23:47:05Z 2019-02-15T23:47:05Z 2019-02-15 2019 2019-11-29T11:11:11Z Artigo de periódico Genomics, v. 20, n. 32, p. 2-13, 2019. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106063 10.1186/s12864-018-5345-y en eng openAccess |
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Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses |
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Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses VIGNATO B. S. COUTINHO, L. L. POLETI, M. D. CESAR, A. S. M. MONCAU, C. T. REGITANO, L. C. de A. BALIEIRO, J. C. C. Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
description |
Positively correlated with carcass weight and animal growth, the ribeye area (REA) and the backfat thickness (BFT) are economic important carcass traits, which impact directly on producer's payment. The selection of these traits has not been satisfactory since they are expressed later in the animal's life and multigene regulated. So, next-generation technologies have been applied in this area to improve animal's selection and better understand the molecular mechanisms involved in the development of these traits. Correlation network analysis, performed by tools like WGCNA (Weighted Correlation Network Analysis), has been used to explore gene-gene interactions and gene-phenotype correlations. Thus, this study aimed to identify putative candidate genes and metabolic pathways that regulate REA and BFT by constructing a gene co-expression network using WGCNA and RNA sequencing data, to better understand genetic and molecular variations behind these complex traits in Nelore cattle. |
author2 |
Bárbara Silva-Vignato, USP; Luiz L. Coutinho, USP; Mirele D. Poleti, USP; Aline S. M. Cesar, USP; Cristina T. Moncau, Universidade Federal de Lavras; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Júlio C. C. Balieiro, USP. |
author_facet |
Bárbara Silva-Vignato, USP; Luiz L. Coutinho, USP; Mirele D. Poleti, USP; Aline S. M. Cesar, USP; Cristina T. Moncau, Universidade Federal de Lavras; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Júlio C. C. Balieiro, USP. VIGNATO B. S. COUTINHO, L. L. POLETI, M. D. CESAR, A. S. M. MONCAU, C. T. REGITANO, L. C. de A. BALIEIRO, J. C. C. |
format |
Artigo de periódico |
topic_facet |
Functional enrichment analysis RNA-Seq data WGCNA Ribeye area Gordura Animal Gado Nelore Carcaça Backfat Thickness Beef carcasses |
author |
VIGNATO B. S. COUTINHO, L. L. POLETI, M. D. CESAR, A. S. M. MONCAU, C. T. REGITANO, L. C. de A. BALIEIRO, J. C. C. |
author_sort |
VIGNATO B. S. |
title |
Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
title_short |
Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
title_full |
Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
title_fullStr |
Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
title_full_unstemmed |
Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle. |
title_sort |
gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in nelore cattle. |
publishDate |
2019-02-15 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106063 |
work_keys_str_mv |
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