Novel putative candidate genes associated with umbilical hernia in pigs.
Abstract: Umbilical hernia is one of the most frequent anatomical defects in pigs in which abdominal contents protrude through the umbilical ring. This condition is considered to have a multifactorial basis in which environmental, infectious and genetic factors play a role. However, a better understanding about the genetic components involved in the umbilical hernia development has not yet been achieved. Although a few studies have mapped QTL for umbilical hernia, just a few candidate genes were reported. Therefore, the aim of this study was to identify genomic regions related to the development of umbilical hernias in pigs and search for potential candidate genes. A GWAS was performed with 92 cases and 233 control crossbred pigs. Five SNPs were associated with umbilical hernia: on SSC4/SSC6/SSC13 and one with unknown position. Candidate genes TBX15 and WARS2 were identified close to the SNP on SSC4. Another two candidate genes were located near the SNP associated with umbilical hernia on SSC13 (LIPI and RBM11). Further validation of these genes should be performed to improve the knowledge about umbilical hernia development in order to improve pig welfare and production by eliminating susceptible animals through genetic selection Resumo: A hérnia umbilical é um dos defeitos anatômicos mais freqüentes em suínos nos quais o conteúdo abdominal se projeta através do anel umbilical. Considera-se que esta condição tem uma base multifatorial na qual fatores ambientais, infecciosos e genéticos desempenham um papel. Entretanto, um melhor entendimento sobre os componentes genéticos envolvidos no desenvolvimento da hérnia umbilical ainda não foi alcançado. Embora alguns estudos tenham mapeado o QTL para a hérnia umbilical, apenas alguns genes candidatos foram relatados. Portanto, o objetivo deste estudo foi identificar regiões genômicas relacionadas ao desenvolvimento de hérnias umbilicais em porcos e buscar potenciais genes candidatos. Um GWAS foi realizado com 92 casos e 233 porcos cruzados de controle. Cinco SNPs foram associados com hérnia umbilical: em SSC4 / SSC6 / SSC13 e um com posição desconhecida. Os genes candidatos TBX15 e WARS2 foram identificados próximos ao SNP em SSC4. Outros dois genes candidatos foram localizados perto do SNP associado à hérnia umbilical na SSC13 (LIPI e RBM11). A validação adicional desses genes deve ser realizada para melhorar o conhecimento sobre o desenvolvimento de hérnia umbilical, a fim de melhorar o bem-estar ea produção de suínos, eliminando os animais suscetíveis por meio da seleção genética
Main Authors: | , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Separatas biblioteca |
Language: | English eng |
Published: |
2018-07-12
|
Subjects: | Hérnia umbilical, Umbilical hernia, Candidate genes, Congenital defect, GWAS, Melhoramento Genético Animal, Suíno, Animal genetic resources, Swine, |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1093239 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-alice-doc-1093239 |
---|---|
record_format |
koha |
spelling |
dig-alice-doc-10932392018-07-13T00:49:18Z Novel putative candidate genes associated with umbilical hernia in pigs. FERNANDES, L. T. ONO, R. K. IBELLI, A. M. G. LAGOS, E. B. MORES, M. A. Z. CANTAO, M. E. LORENZETTI, W. R. PEIXOTO, J. de O. PEDROSA, V. B. LEDUR, M. C. LANA TEIXEIRA FERNANDES, CEDISA; RAFAEL KEITH ONO; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; UEPG; MARCOS ANTONIO ZANELLA MORES, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; WILLIAM RAPHAEL LORENZETTI, UDESC/Chapecó; JANE DE OLIVEIRA PEIXOTO, CNPSA; VICTOR BRENO PEDROSA; MONICA CORREA LEDUR, CNPSA. Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine Abstract: Umbilical hernia is one of the most frequent anatomical defects in pigs in which abdominal contents protrude through the umbilical ring. This condition is considered to have a multifactorial basis in which environmental, infectious and genetic factors play a role. However, a better understanding about the genetic components involved in the umbilical hernia development has not yet been achieved. Although a few studies have mapped QTL for umbilical hernia, just a few candidate genes were reported. Therefore, the aim of this study was to identify genomic regions related to the development of umbilical hernias in pigs and search for potential candidate genes. A GWAS was performed with 92 cases and 233 control crossbred pigs. Five SNPs were associated with umbilical hernia: on SSC4/SSC6/SSC13 and one with unknown position. Candidate genes TBX15 and WARS2 were identified close to the SNP on SSC4. Another two candidate genes were located near the SNP associated with umbilical hernia on SSC13 (LIPI and RBM11). Further validation of these genes should be performed to improve the knowledge about umbilical hernia development in order to improve pig welfare and production by eliminating susceptible animals through genetic selection Resumo: A hérnia umbilical é um dos defeitos anatômicos mais freqüentes em suínos nos quais o conteúdo abdominal se projeta através do anel umbilical. Considera-se que esta condição tem uma base multifatorial na qual fatores ambientais, infecciosos e genéticos desempenham um papel. Entretanto, um melhor entendimento sobre os componentes genéticos envolvidos no desenvolvimento da hérnia umbilical ainda não foi alcançado. Embora alguns estudos tenham mapeado o QTL para a hérnia umbilical, apenas alguns genes candidatos foram relatados. Portanto, o objetivo deste estudo foi identificar regiões genômicas relacionadas ao desenvolvimento de hérnias umbilicais em porcos e buscar potenciais genes candidatos. Um GWAS foi realizado com 92 casos e 233 porcos cruzados de controle. Cinco SNPs foram associados com hérnia umbilical: em SSC4 / SSC6 / SSC13 e um com posição desconhecida. Os genes candidatos TBX15 e WARS2 foram identificados próximos ao SNP em SSC4. Outros dois genes candidatos foram localizados perto do SNP associado à hérnia umbilical na SSC13 (LIPI e RBM11). A validação adicional desses genes deve ser realizada para melhorar o conhecimento sobre o desenvolvimento de hérnia umbilical, a fim de melhorar o bem-estar ea produção de suínos, eliminando os animais suscetíveis por meio da seleção genética 2018-07-13T00:49:11Z 2018-07-13T00:49:11Z 2018-07-12 2018 2018-07-13T00:49:11Z Separatas In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1093239 en eng openAccess |
institution |
EMBRAPA |
collection |
DSpace |
country |
Brasil |
countrycode |
BR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-alice |
tag |
biblioteca |
region |
America del Sur |
libraryname |
Sistema de bibliotecas de EMBRAPA |
language |
English eng |
topic |
Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine |
spellingShingle |
Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine FERNANDES, L. T. ONO, R. K. IBELLI, A. M. G. LAGOS, E. B. MORES, M. A. Z. CANTAO, M. E. LORENZETTI, W. R. PEIXOTO, J. de O. PEDROSA, V. B. LEDUR, M. C. Novel putative candidate genes associated with umbilical hernia in pigs. |
description |
Abstract: Umbilical hernia is one of the most frequent anatomical defects in pigs in which abdominal contents protrude through the umbilical ring. This condition is considered to have a multifactorial basis in which environmental, infectious and genetic factors play a role. However, a better understanding about the genetic components involved in the umbilical hernia development has not yet been achieved. Although a few studies have mapped QTL for umbilical hernia, just a few candidate genes were reported. Therefore, the aim of this study was to identify genomic regions related to the development of umbilical hernias in pigs and search for potential candidate genes. A GWAS was performed with 92 cases and 233 control crossbred pigs. Five SNPs were associated with umbilical hernia: on SSC4/SSC6/SSC13 and one with unknown position. Candidate genes TBX15 and WARS2 were identified close to the SNP on SSC4. Another two candidate genes were located near the SNP associated with umbilical hernia on SSC13 (LIPI and RBM11). Further validation of these genes should be performed to improve the knowledge about umbilical hernia development in order to improve pig welfare and production by eliminating susceptible animals through genetic selection Resumo: A hérnia umbilical é um dos defeitos anatômicos mais freqüentes em suínos nos quais o conteúdo abdominal se projeta através do anel umbilical. Considera-se que esta condição tem uma base multifatorial na qual fatores ambientais, infecciosos e genéticos desempenham um papel. Entretanto, um melhor entendimento sobre os componentes genéticos envolvidos no desenvolvimento da hérnia umbilical ainda não foi alcançado. Embora alguns estudos tenham mapeado o QTL para a hérnia umbilical, apenas alguns genes candidatos foram relatados. Portanto, o objetivo deste estudo foi identificar regiões genômicas relacionadas ao desenvolvimento de hérnias umbilicais em porcos e buscar potenciais genes candidatos. Um GWAS foi realizado com 92 casos e 233 porcos cruzados de controle. Cinco SNPs foram associados com hérnia umbilical: em SSC4 / SSC6 / SSC13 e um com posição desconhecida. Os genes candidatos TBX15 e WARS2 foram identificados próximos ao SNP em SSC4. Outros dois genes candidatos foram localizados perto do SNP associado à hérnia umbilical na SSC13 (LIPI e RBM11). A validação adicional desses genes deve ser realizada para melhorar o conhecimento sobre o desenvolvimento de hérnia umbilical, a fim de melhorar o bem-estar ea produção de suínos, eliminando os animais suscetíveis por meio da seleção genética |
author2 |
LANA TEIXEIRA FERNANDES, CEDISA; RAFAEL KEITH ONO; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; UEPG; MARCOS ANTONIO ZANELLA MORES, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; WILLIAM RAPHAEL LORENZETTI, UDESC/Chapecó; JANE DE OLIVEIRA PEIXOTO, CNPSA; VICTOR BRENO PEDROSA; MONICA CORREA LEDUR, CNPSA. |
author_facet |
LANA TEIXEIRA FERNANDES, CEDISA; RAFAEL KEITH ONO; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; UEPG; MARCOS ANTONIO ZANELLA MORES, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; WILLIAM RAPHAEL LORENZETTI, UDESC/Chapecó; JANE DE OLIVEIRA PEIXOTO, CNPSA; VICTOR BRENO PEDROSA; MONICA CORREA LEDUR, CNPSA. FERNANDES, L. T. ONO, R. K. IBELLI, A. M. G. LAGOS, E. B. MORES, M. A. Z. CANTAO, M. E. LORENZETTI, W. R. PEIXOTO, J. de O. PEDROSA, V. B. LEDUR, M. C. |
format |
Separatas |
topic_facet |
Hérnia umbilical Umbilical hernia Candidate genes Congenital defect GWAS Melhoramento Genético Animal Suíno Animal genetic resources Swine |
author |
FERNANDES, L. T. ONO, R. K. IBELLI, A. M. G. LAGOS, E. B. MORES, M. A. Z. CANTAO, M. E. LORENZETTI, W. R. PEIXOTO, J. de O. PEDROSA, V. B. LEDUR, M. C. |
author_sort |
FERNANDES, L. T. |
title |
Novel putative candidate genes associated with umbilical hernia in pigs. |
title_short |
Novel putative candidate genes associated with umbilical hernia in pigs. |
title_full |
Novel putative candidate genes associated with umbilical hernia in pigs. |
title_fullStr |
Novel putative candidate genes associated with umbilical hernia in pigs. |
title_full_unstemmed |
Novel putative candidate genes associated with umbilical hernia in pigs. |
title_sort |
novel putative candidate genes associated with umbilical hernia in pigs. |
publishDate |
2018-07-12 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1093239 |
work_keys_str_mv |
AT fernandeslt novelputativecandidategenesassociatedwithumbilicalherniainpigs AT onork novelputativecandidategenesassociatedwithumbilicalherniainpigs AT ibelliamg novelputativecandidategenesassociatedwithumbilicalherniainpigs AT lagoseb novelputativecandidategenesassociatedwithumbilicalherniainpigs AT moresmaz novelputativecandidategenesassociatedwithumbilicalherniainpigs AT cantaome novelputativecandidategenesassociatedwithumbilicalherniainpigs AT lorenzettiwr novelputativecandidategenesassociatedwithumbilicalherniainpigs AT peixotojdeo novelputativecandidategenesassociatedwithumbilicalherniainpigs AT pedrosavb novelputativecandidategenesassociatedwithumbilicalherniainpigs AT ledurmc novelputativecandidategenesassociatedwithumbilicalherniainpigs |
_version_ |
1756024861544677376 |