Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice

Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice

Tomato consumption is associated with many health benefits including lowered risk for developing certain cancers. However, the effects of tomato consumption on gene expression and the chemical profile of mammalian liver are not well defined. Overall design: C57BL/6 mice (n=11-12/group) were fed a macronutrient matched diet containing either 10% red tomato, 10% tangerine tomato, or no tomato powder for 6 weeks after weaning. RNA-Seq followed by gene set enrichment analyses indicated that tomato type and consumption, in general, altered expression of phase I and II xenobiotic metabolizing genes.

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Bibliographic Details
Main Author: Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524)
Format: Dataset biblioteca
Published: 2022
Subjects:Genetics, Mus musculus, eEukaryotes,
Online Access:https://figshare.com/articles/dataset/Transcriptomics_and_Metabolomics_Reveal_Liver_Metabolic_Changes_and_Phytochemical_Deposition_Occurring_after_Tomato_Consumption_in_Mice/25090790
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id dat-usda-us-article25090790
record_format figshare
spelling dat-usda-us-article250907902022-12-17T00:00:00Z Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524) Genetics Mus musculus eEukaryotes Tomato consumption is associated with many health benefits including lowered risk for developing certain cancers. However, the effects of tomato consumption on gene expression and the chemical profile of mammalian liver are not well defined. Overall design: C57BL/6 mice (n=11-12/group) were fed a macronutrient matched diet containing either 10% red tomato, 10% tangerine tomato, or no tomato powder for 6 weeks after weaning. RNA-Seq followed by gene set enrichment analyses indicated that tomato type and consumption, in general, altered expression of phase I and II xenobiotic metabolizing genes. 2022-12-17T00:00:00Z Dataset Dataset 10113/AF25090790 https://figshare.com/articles/dataset/Transcriptomics_and_Metabolomics_Reveal_Liver_Metabolic_Changes_and_Phytochemical_Deposition_Occurring_after_Tomato_Consumption_in_Mice/25090790 Copyright Undetermined
institution USDA US
collection Figshare
country Estados Unidos
countrycode US
component Datos de investigación
access En linea
databasecode dat-usda-us
tag biblioteca
region America del Norte
libraryname National Agricultural Library of USDA
topic Genetics
Mus musculus
eEukaryotes
spellingShingle Genetics
Mus musculus
eEukaryotes
Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524)
Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
description Tomato consumption is associated with many health benefits including lowered risk for developing certain cancers. However, the effects of tomato consumption on gene expression and the chemical profile of mammalian liver are not well defined. Overall design: C57BL/6 mice (n=11-12/group) were fed a macronutrient matched diet containing either 10% red tomato, 10% tangerine tomato, or no tomato powder for 6 weeks after weaning. RNA-Seq followed by gene set enrichment analyses indicated that tomato type and consumption, in general, altered expression of phase I and II xenobiotic metabolizing genes.
format Dataset
author Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524)
author_facet Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524)
author_sort Pediatrics, USDA-ARS Children's Nutrition Research Center (18797524)
title Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
title_short Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
title_full Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
title_fullStr Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
title_full_unstemmed Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice
title_sort transcriptomics and metabolomics reveal liver metabolic changes and phytochemical deposition occurring after tomato consumption in mice
publishDate 2022
url https://figshare.com/articles/dataset/Transcriptomics_and_Metabolomics_Reveal_Liver_Metabolic_Changes_and_Phytochemical_Deposition_Occurring_after_Tomato_Consumption_in_Mice/25090790
work_keys_str_mv AT pediatricsusdaarschildrensnutritionresearchcenter18797524 transcriptomicsandmetabolomicsreveallivermetabolicchangesandphytochemicaldepositionoccurringaftertomatoconsumptioninmice
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