Steroid-Protein Interactions II [electronic resource] /

I. Steroid-Protein Interactions Revisited -- II. Serum Albumin -- A. The Steroid Binding Site of BSA and HSA -- B. Relation of Fatty Acid to Steroid Binding -- C. Steroid Binding to Oligomers of HSA -- D. Characteristics of Steroid Binding to Albumin -- E. Spin Label Studies -- III. ?1-Acid Glycoprotein (AAG, Orosomucoid) -- A. Isolation of AAG -- B. Studies on AAG Synthesis -- C. Chemical Properties -- D. Molecular Properties -- E. Interaction with Steroids -- IV. Some Recent Methodological Developments -- 1. Measurement of Unbound Steroid -- 2. Adsorption and Related Methods -- 3. Electrophoretic Methods -- 4. Equilibrium Dialysis, Scatchard Plots and Related Procedures -- V. Corticosteroid-Binding Globulin (CBG) -- A. Biosynthesis -- B. Hormonal and Other Influences on Blood CBG Level -- C. General Characteristics of CBG in Nonmammalian Vertebrates -- D. General Characteristics of CBG in Nonhuman Mammals -- E. CBG-Like Steroid Binders -- F. Biological Characteristics of CBG in Human Blood -- G. Physicochemical Properties of Rabbit CBG -- H. Physicochemical and Binding Properties of Guinea Pig CBG -- I. Physicochemical and Binding Properties of Human CBG -- VI. Progesterone-Binding Globulin (PBG) -- A. Initial Studies -- B. Occurrence -- C. Origin -- D. Isolation and Physicochemical Properties -- E. Interaction with Steroids -- F. Binding Specificity -- VII. Sex Steroid-Binding Protein (SBP) -- A. Introduction -- B. Significance -- C. Methods to Determine SBP Concentration; Data for Human Blood -- D. SPB in Nonmammalian Vertebrates -- E. SBP in Nonhuman Mammals -- F. Occurrence and Development of SBP in Humans -- G. Influence of Endocrines on SBP -- H. SBP in Pathological Conditions -- I. Physicochemical Properties of Human SBP -- J. Steroid Binding to Human SBP -- K. The Binding Site of Human SBP -- VIII. Hydrophobicity and Hydrophilicity of Steroid Binding Sites -- 1. Affinity Constants and Free Energy of Binding -- 2. Dissociation Rates -- 3. Hydrophobicity -- 4. Specificity of Binding; Additivity of ??G° -- 5. The Steroid Binding Site -- IX. Androgen-Binding Protein (ABP) -- A. Introduction -- B. ABP in the Rat -- C. ABP in the Rabbit -- D. ABP in Ram, Goat, and Bull -- E. ABP in Man -- F. Possible Function of ABP -- X. Prostatic Steroid-Binding Protein (PSB) -- A. Early Observations -- B. General Characteristics of Rat PSB and Its Regulation -- C. Physicochemical and Steroid Binding Properties of Rat PSB -- D. Synthesis of PSB by Translation -- E. Structure of PSB Subunit Components -- F. PSB in Man and Other Species -- XI. Alpha-Fetoprotein -- A. Basic Observations -- B. Purification and Characterization of AFP from Different Species -- C. Binding of Estrogens to AFP -- D. Biological Role of AFP -- XII. Uteroglobin (Blastokinin) -- A. Initial Observations -- B. Induction of Uteroglobin -- C. Antibodies Against Uteroglobin -- D. Occurrence of Uteroglobin -- E. Physicochemical Properties of Uteroglobin -- F. Biosynthesis of Uteroglobin -- G. Steroid Binding to Uteroglobin -- H. The Enigmatic Biological Function of Uteroglobin -- XIII. Ecdysteroid-Binding Proteins -- A. Ecdysteroids in the Hemolymph of Insects -- B. Proteins Binding with Low Affinity -- C. High-Affinity Binding -- XIV. Sterol Carrier Protein (SCP) -- A. Introduction -- B. SCP in Sterol Biosynthesis -- C. Properties of Sterol Carrier Proteins -- D. SCP-Like Proteins in Adrenal and Other Organs -- E. Additional Cholesterol-Transporting Proteins -- XV. Vitamin D- and Secosteroid Hormone-Binding Serum Proteins -- A. Early Observations -- B. Competitive Binding Analysis Using Vitamin D-Binding Proteins -- C. Determination of Vitamin D-Binding Protein (DBP) -- D. General Aspects of DBP in Various Species -- E. Human DBP -- F. Characterization of DBP in Other Vertebrates -- G. DBP-Actin Complex -- H. Hepatic Origin of DBP -- I. Vitamin D Receptors -- J. Physiological Significance of DBP -- XVI. Antibodies to Steroid Hormones -- A. General Aspects -- B. Antibodies Against Digitalis Glycosides and Contraceptive Steroids -- C. Antibodies Against Estrogens -- D. Antibodies Against Androgens -- E. Antibodies Against Progestogens -- F. Antibodies Against Corticosteroids -- G. Physiological Effects of Steroid Antibodies -- XVII. Binding of Steroids to Transforming Enzymes -- A. ?5-3-Ketosteroid Isomerase -- B. 3-Hydroxysteroid Oxidoreductases -- C. Estradiol 17?-Dehydrogenase from Human Placenta and Other Sources -- D. Glutamic Dehydrogenase -- E. 20?-Hydroxy steroid Dehydrogenase from Streptomyces hydrogenans -- A. List of Abbreviations and Symbols -- B. Greek Symbols -- C. Names of Steroids and Other Compounds Used in the Monograph -- D. Adsorption of Steroids to Rubber and Plastics.

Bibliographic Details

Main Authors:	Westphal, Ulrich. author., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Berlin, Heidelberg : Springer Berlin Heidelberg, 1986
Subjects:	Medicine., Endocrinology., Biochemistry., Medicine & Public Health., Biochemistry, general.,
Online Access:	http://dx.doi.org/10.1007/978-3-642-82486-9
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