![Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 /](/search/themes/bootstrap3/images/libros.png)
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 /
The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Texto biblioteca |
| Language: | eng |
| Published: |
Boston, MA : Springer US,
1987
|
| Subjects: | Medicine., Pharmacology., Cardiology., Nephrology., Medicine & Public Health., Pharmacology/Toxicology., |
| Online Access: | http://dx.doi.org/10.1007/978-1-4613-2067-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
KOHA-OAI-TEST:218625 |
|---|---|
| record_format |
koha |
| institution |
COLPOS |
| collection |
Koha |
| country |
México |
| countrycode |
MX |
| component |
Bibliográfico |
| access |
En linea En linea |
| databasecode |
cat-colpos |
| tag |
biblioteca |
| region |
America del Norte |
| libraryname |
Departamento de documentación y biblioteca de COLPOS |
| language |
eng |
| topic |
Medicine. Pharmacology. Cardiology. Nephrology. Medicine & Public Health. Nephrology. Cardiology. Pharmacology/Toxicology. Medicine. Pharmacology. Cardiology. Nephrology. Medicine & Public Health. Nephrology. Cardiology. Pharmacology/Toxicology. |
| spellingShingle |
Medicine. Pharmacology. Cardiology. Nephrology. Medicine & Public Health. Nephrology. Cardiology. Pharmacology/Toxicology. Medicine. Pharmacology. Cardiology. Nephrology. Medicine & Public Health. Nephrology. Cardiology. Pharmacology/Toxicology. Andreucci, V. E. editor. Canton, Antonio Dal. editor. SpringerLink (Online service) Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| description |
The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice. |
| format |
Texto |
| topic_facet |
Medicine. Pharmacology. Cardiology. Nephrology. Medicine & Public Health. Nephrology. Cardiology. Pharmacology/Toxicology. |
| author |
Andreucci, V. E. editor. Canton, Antonio Dal. editor. SpringerLink (Online service) |
| author_facet |
Andreucci, V. E. editor. Canton, Antonio Dal. editor. SpringerLink (Online service) |
| author_sort |
Andreucci, V. E. editor. |
| title |
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| title_short |
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| title_full |
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| title_fullStr |
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| title_full_unstemmed |
Diuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / |
| title_sort |
diuretics: basic, pharmacological, and clinical aspects [electronic resource] : proceedings of the international meeting on diuretics, sorrento, italy, may 26–30, 1986 / |
| publisher |
Boston, MA : Springer US, |
| publishDate |
1987 |
| url |
http://dx.doi.org/10.1007/978-1-4613-2067-8 |
| work_keys_str_mv |
AT andreucciveeditor diureticsbasicpharmacologicalandclinicalaspectselectronicresourceproceedingsoftheinternationalmeetingondiureticssorrentoitalymay26301986 AT cantonantoniodaleditor diureticsbasicpharmacologicalandclinicalaspectselectronicresourceproceedingsoftheinternationalmeetingondiureticssorrentoitalymay26301986 AT springerlinkonlineservice diureticsbasicpharmacologicalandclinicalaspectselectronicresourceproceedingsoftheinternationalmeetingondiureticssorrentoitalymay26301986 |
| _version_ |
1756269914984808448 |
| spelling |
KOHA-OAI-TEST:2186252018-07-30T23:55:21ZDiuretics: Basic, Pharmacological, and Clinical Aspects [electronic resource] : Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 / Andreucci, V. E. editor. Canton, Antonio Dal. editor. SpringerLink (Online service) textBoston, MA : Springer US,1987.engThe need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.I. Historical Review. -- II. Effects of Diuretics on Ion Transport. -- III. Effects of Diuretics on Tubular Transport. -- IV. Pharmacokinetics. -- V. Endogenous Natriuretic Factors. -- VI. Aquaretics. -- VII. Diuretics and Hypertension. -- VIII. Diuretics and Cardiac Disease -- IX. Diuretics and Renal Disease. -- X. Diuretics in Cirrhosis. -- XI. Diuretics and Stone Formation. -- XII. Side Effects of Diuretic Therapy. -- XIII. Effects of Diuretics on Water and Electrolyte Excretion. -- XIV. Diuretics in Renal Investigation. -- XV. Effects of Diuretics on Renal Function. -- XVI. Diuretics and Prostaglandins.The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.Medicine.Pharmacology.Cardiology.Nephrology.Medicine & Public Health.Nephrology.Cardiology.Pharmacology/Toxicology.Springer eBookshttp://dx.doi.org/10.1007/978-1-4613-2067-8URN:ISBN:9781461320678 |