Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /

Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /

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The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.

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Main Authors: Greeff, Kurt. editor., SpringerLink (Online service)
Format: Texto biblioteca
Language:eng
Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 1981
Subjects:Medicine., Pharmacy., Pharmacology., Biomedicine., Pharmacology/Toxicology.,
Online Access:http://dx.doi.org/10.1007/978-3-642-68166-0
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spelling KOHA-OAI-TEST:2167392018-07-30T23:52:41ZCardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology / Greeff, Kurt. editor. SpringerLink (Online service) textBerlin, Heidelberg : Springer Berlin Heidelberg,1981.engThe pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.Pharmacokinetics — Distribution, Metabolism, and Elimination -- 1 Pharmacokinetics of Digitoxin -- 2 Pharmacokinetics of Digoxin and Derivatives -- 3 Pharmacokinetics of Strophanthus Glycosides -- 4 Pharmacokinetics of Squill Glycosides -- Pharmacokinetics — Additional Pharmacokinetic Parameters of Cardiac Glycosides -- 5 Plasma Protein Binding of Cardiac Glycosides -- 6 Intestinal Absorption and Secretion of Cardiac Glycosides -- 7 Cardiac Uptake and Binding of Cardiac Glycosides -- 8 Bioavailability of Cardiac Glycosides -- 9 Pharmaceutical Quality Control Standards for Cardiac Glycosides -- Clinical Pharmacology -- 10 Effects of Cardiac Glycosides on the Failing and Nonfailing Heart -- 11 The Effect of Disease on Cardiac Glycoside Pharmacokinetics -- 12 Clinical Indications and Choice of Cardiac Glycosides, Clinical Conditions Influencing Glycoside Effects -- 13 Side Effects and Intoxication of Cardiac Glycosides: Manifestations and Treatment -- 14 Interactions Between Cardiac Glycosides and Other Substances in the Body -- Author Index.The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.Medicine.Pharmacy.Pharmacology.Biomedicine.Pharmacology/Toxicology.Pharmacy.Springer eBookshttp://dx.doi.org/10.1007/978-3-642-68166-0URN:ISBN:9783642681660
institution COLPOS
collection Koha
country México
countrycode MX
component Bibliográfico
access En linea
En linea
databasecode cat-colpos
tag biblioteca
region America del Norte
libraryname Departamento de documentación y biblioteca de COLPOS
language eng
topic Medicine.
Pharmacy.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Pharmacy.
Medicine.
Pharmacy.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Pharmacy.
spellingShingle Medicine.
Pharmacy.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Pharmacy.
Medicine.
Pharmacy.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Pharmacy.
Greeff, Kurt. editor.
SpringerLink (Online service)
Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
description The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.
format Texto
topic_facet Medicine.
Pharmacy.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Pharmacy.
author Greeff, Kurt. editor.
SpringerLink (Online service)
author_facet Greeff, Kurt. editor.
SpringerLink (Online service)
author_sort Greeff, Kurt. editor.
title Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
title_short Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
title_full Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
title_fullStr Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
title_full_unstemmed Cardiac Glycosides [electronic resource] : Part II: Pharmacokinetics and Clinical Pharmacology /
title_sort cardiac glycosides [electronic resource] : part ii: pharmacokinetics and clinical pharmacology /
publisher Berlin, Heidelberg : Springer Berlin Heidelberg,
publishDate 1981
url http://dx.doi.org/10.1007/978-3-642-68166-0
work_keys_str_mv AT greeffkurteditor cardiacglycosideselectronicresourcepartiipharmacokineticsandclinicalpharmacology
AT springerlinkonlineservice cardiacglycosideselectronicresourcepartiipharmacokineticsandclinicalpharmacology
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