The Molecular Biology of Down Syndrome [electronic resource] /

Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration -- Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome -- The Down Syndrome critical region -- Neuropathology -- c-fos expression in brains of patients with Down Syndrome -- Neuronal cell death in Down’s syndrome -- Altered Gene expression in fetal Down Syndrome brain as revealed by the Gene huntinG technique of subtractive hybridization -- Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization -- Molecular misreadinG of Genes in Down syndrome as a model for the Alzheimer type of neurodegeneration -- Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level -- Gene expression relevant to Down Syndrome: problems and approaches -- Isolation and analysis of chromosome 21 Genes potentially involved in Down Syndrome -- Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome -- Serotonin (5-HT) in brains of adult patients with Down Syndrome -- Mechanisms of neuronal death in Down’s syndrome -- Impaired brain Glucose metabolism in patients with Down Syndrome -- Oxidative stress and neural dysfunction in Down Syndrome -- Expression of the transcription factor ETS2 in brain of patients with Down Syndrome — evidence against the overexpression-Gene dosage hypothesis -- Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down Syndrome -- The “Gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down Syndrome -- Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome -- Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease -- Increased levels of 14-3-3 Gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down Syndrome -- Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin -- Overexpression of DNAse I in brain of patients with Down Syndrome.