Toxicological Aspects of Food Safety [electronic resource] : Proceedings of the European Society of Toxicology. Meeting held in Copenhagen, June 19–22, 1977 /

Young Scientists Award Lecture 1977: An Investigation into the Value of Some Clinical Biochemical Tests in the Detection of Minimal Changes in Liver Morphology and Function in the Rat -- Toxicological Aspects of Food Safety. Introduction to the Symposium -- Nutritional Evaluation of Low-Erucic-Acid Rapeseed Oils -- Food Additives -- Pesticides and Heavy Metals as Food Contaminants -- Toxicokinetics -- Toxicological Aspects of Food Safety — Carcinogenicity and Mutagenicity -- Significance of Induction Phenomena -- Evaluation of Food Safety. National and International Aspects -- Drug Biotransformation and Hepatotoxicity. Studies with Bromobenzene in Isolated Hepatocytes -- Hepatotoxicity of Bile Acids with Special Reference to Cheno-Treatment (Abstract) -- Metabolic Activation of Methyldopa and Other Catechols -- Clinical Aspects of Drug-Induced Hepatitis -- Hepatotoxicity in Patients with Liver Disease -- Halothane Hepatitis -- Hypersensitivity Reactions to Food Colours with Special Reference to the Natural Colour Annatto Extract (Butter Colour) -- The Use of Radionuclides for the Quantitative Evaluation of Drug Local Irritancy (Abstract) -- Stimulation of DNA Synthesis in Mouse and Rat Lung Following Administration of Butylated Hydroxytoluene -- Effects of Rapidly Phosphorylated Substrates Fructose, Sorbitol, Xylitol (Glycerol): Toxic or Metabolic -- Study and Evaluation of Organic Lead Levels in Fishes and Phytoplankton Near Otranto (Abstract) -- Drug-Induced Changes in Serum Alkaline Phosphatase and Alanine Aminotransferase Activities not Related to Hepatic Injuries -- Evaluation of Organ Weight Differences in Toxicological Experiments -- Comparative Cardiovascular Toxicity of Trazodone and Imipramine in the Rat -- Liver Injury and Multiple Drug Therapy -- Hepatotoxicity of Citalopram in Rats and First-Pass Metabolism -- Toxicologic Findings of 3-Aryl-triene-steroidal-16,17-acetonamide (ATSA) (Abstract) -- Biochemical Effects of Chronically Administered Suspending Agents on Mitochondrial Metabolism and Hepatic Mixed Function Oxidases in Rat, Mice and Hamster -- Effect of Ethylenethiourea on Hepatic Microsomal Enzymes in the Rat -- Comparative Study of the Protective Effect of an Anabolic Steroid. The 19-Nortestosterone-Phenylpropionate (19NTPP), on Liver Steatosis Induced by Amanita phalloides and White Phosphorus in Rats -- Experimental Study of Bonaphthon in the Maternal-Embryonic Complex (Abstract) -- Chimpanzees Sulfate Lithocholate Similar to Man (Abstract) -- Influence of Some Thiol Compounds on the CCl4 Hepatotoxicity (Abstract) -- Thromboelastography Behaviour in Rats Submitted to Experimental Liver Intoxication (Abstract) -- Routine Clinical Electroretinography in Dogs (Abstract) -- A New Procedure for Estimation of Nitrovin and Carbadox Residues and Their Metabolites in Food of Animal Origin -- Glutathione Turnover in Isolated Hepatocytes (Abstract) -- Covalent Binding of 2,4-Diaminoanisole and 2,4-Diaminotoluene in vivo -- Comparative Research of Certain Methods in Evaluation of Hepatotoxicity of Chemical Agents (Abstract) -- Hepatotoxic Effect of Thioacetamide (TAM) on NADP-Linked Enzymes, Aminotransferases and Glutamate Dehydrogenase -- A Histological Review of the Rat Liver Poisoned by Carbontetrachloride and Treated by Piracetam (Abstract) -- The Effect of Piracetam in Rats Poisoned by Carbontetrachloride -- Hepato- and Thyreotoxicity of Tifemoxone -- Toxicological Studies on a New Veterinary Antibiotic Turimycin -- Metabolism of 2,4,5,2?,5?-Pentachlorobiphenyl by Lung and Liver Microsomes -- Hepatic Clearance and Disposition of Hydroxyethylrutosides -- Changes in the Hepatic Copper Content after Treatment with Foreign Compounds -- Absorption and Excretion of 1-Amino-2-Naphthol-6-Sulphonic Acid in Rats and Rabbits -- Drug Excretion into Eggs. An Autoradiographic Study -- The Metabolism of 3H-Benzo(a)pyrene by Hepatic Microsomes from Rats Treated with Tetrachlorodibenzo-p-dioxin (Abstract) -- Induction of Drug Metabolizing Enzymes in Different Rat Tissues by TCDD -- Lysosomal Enzymes in Hepatic Injury Induced by Bromobenzene -- Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment -- A Simple and Sensitive Assay of 7-Ethoxycoumarin in Deethylation (Abstract) -- Induction of Arylhydrocarbon Hydroxylase and UDP Glucuronosyl Transferase by PCB in Hepatic Cell Cultures -- Enhancement of Cytosolic Carboxylesterase by Phenobarbital in the Rat -- A New Method for Hepatocyte Function Exploration (T.M.B. Test) Applied to the Rat in Experimental Toxicology (Abstract) -- Modifying Effects of Styrene on the Catalytic Properties of Some Microsomal Enzymes -- Specific Modification of the Properties of the N-Hydroxylase. Relationship with Carcinogenesis by Aromatic Amides -- A Very Sensitive Gas Chromatographic Method for the Evaluation of Styrene Oxidase and Styrene Oxide Hydratase Activities -- A Gas Chromatographic Method for the Evaluation of the Vinyl Epoxidase Activity -- The Fate of Curcumin in the Rat (Abstract) -- The Use of Food Additives in Sweden -- Hemiglobin Formation in vitro Induced by Azo Dyes and Their Metabolites -- Peroral Toxicity of Orange RN in Pigs. Early Haematological Changes -- Peroral Toxicity of Orange RN in Pigs. Ultrastructure of Hepatic Lesions (Abstract) -- Toxicology of Triethyllead, Methylmercury and Cadmium, Determined in Chick Embryo Brain Cell Cultures -- Reversible Inhibition of Spermatogenesis with an Indenopyridine (20–438) -- Relative Teratogenicity of Selected Anhydrides (Abstract) -- Effects of Rapeseed Oil Compared to Hydrogenated Marine Oil in Rats. Histopathological Effects of Erucic Acid and Isomers on the Heart -- Changes in Liver Tyrosine Aminotransferase after Acute and Chronic Administration of Morphine in the Rat -- Retarded Elimination of a High-Molecular Enzyme-Substrate-Complex after Hydroxyethyl-Starch-Infusion -- Drug Metabolism in Man: In vivo and in vitro Correlations -- Pharmacokinetics of Dextropropoxyphene in Acute Poisoning -- Suitability of Different Breeds of Rabbits for Experimental Atherosclerosis (Abstract) -- Results of Comparative Toxicity Tests on Mini-Pigs, Beagles and Wistar-Rats with d-Norgestrel (Abstract) -- Metabolism of L(+)- and D(-)-Tartaric Acids in Different Animal Species -- Influence of Diet and Strain of Rat on Kidney Damage Observed in Toxicity Studies -- Influence of Drugs on Bile Acid Excretion -- Pharmacological Properties of the Optical Isomers of Ketamine. (Abstract) -- The Influence of Arrhythmogenic Substances on the E.C.G. of Rats Calcified by High Doses of Vitamin D2 -- Extrapolation of Carcinogenicity Data to Low Doses with a Dose-Response Study of the Binding of Benzo(a)pyrene to Rat Liver DNA -- A Closed Inhalation System for Pharmacokinetic and Metabolism Studies of Volatile Compounds with Small Laboratory Animals -- Effects of Diazepam on DFP Intoxicated Mice in the Absence and Presence of Obidoxime (Abstract) -- Pharmacological and Toxicological Investigations on the New Bulgarian Drug Lonetil (Abstract) -- Metabolism of Benzo(a)pyrene Catalyzed by Human Lung Microsomes (Abstract) -- Stimulation of the Synthesis, in vivo, of Zoxazolamine Hydroxylase in Young Female Rat by Bixa orellana L. Extract (Abstract) -- Structural and Biochemical Changes in Rat Hepatic and Extrahepatic Tissues Following a Single Oral Dose of TCDD (Abstract) -- Author Index.