Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages
Background: The evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite's evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published. Methods: The current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analytical variables and results that have given rise to interpretations of putative patterns of genetic diversity and diversification of T. cruzi lineages, discrete typing units (DTUs), and populations, and their associations with hosts, vectors, and geographical distribution that have been interpreted as evidence for parasite subpopulation specificities. Results: Few studies use hypothesis-driven or quantitative analysis for T. cruzi phylogeny (16/58 studies) or phylogeography (10/13). Among these, only one phylogenetic and five phylogeographic studies analyzed molecular markers directly from tissues (i.e. not from isolates). Analysis of T. cruzi DTU or lineage niche and its geographical projection demonstrate extensive sympatry among all clades across the continent and no significant niche differences among DTUs. DTU beta-diversity was high, indicating diverse host assemblages across regions, while host dissimilarity was principally due to host species turnover and to a much lesser degree to nestedness. DTU-host order specificities appear related to trophic or microenvironmental interactions. Conclusions: More rigorous study designs and analyses will be required to discern evolutionary processes and the impact of landscape modification on population dynamics and risk for T. cruzi transmission to humans.
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Format: | Texto biblioteca |
Language: | eng |
Subjects: | Trypanosoma cruzi, Nicho (Ecología), Mamíferos, Filogenética, Enfermedad de chagas, Zoogeografía, |
Online Access: | https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1918-2 |
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Trypanosoma cruzi Nicho (Ecología) Mamíferos Filogenética Enfermedad de chagas Zoogeografía Trypanosoma cruzi Nicho (Ecología) Mamíferos Filogenética Enfermedad de chagas Zoogeografía |
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Trypanosoma cruzi Nicho (Ecología) Mamíferos Filogenética Enfermedad de chagas Zoogeografía Trypanosoma cruzi Nicho (Ecología) Mamíferos Filogenética Enfermedad de chagas Zoogeografía Izeta Alberdi, Amaia Doctor autor 15602 Ibarra Cerdeña, Carlos Napoleón autor 13200 Moo Llanes, David Alejandro autor 13403 Ramsey Willoquet, Janine M. Doctora autor 14239 Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
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Background: The evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite's evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published. Methods: The current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analytical variables and results that have given rise to interpretations of putative patterns of genetic diversity and diversification of T. cruzi lineages, discrete typing units (DTUs), and populations, and their associations with hosts, vectors, and geographical distribution that have been interpreted as evidence for parasite subpopulation specificities. Results: Few studies use hypothesis-driven or quantitative analysis for T. cruzi phylogeny (16/58 studies) or phylogeography (10/13). Among these, only one phylogenetic and five phylogeographic studies analyzed molecular markers directly from tissues (i.e. not from isolates). Analysis of T. cruzi DTU or lineage niche and its geographical projection demonstrate extensive sympatry among all clades across the continent and no significant niche differences among DTUs. DTU beta-diversity was high, indicating diverse host assemblages across regions, while host dissimilarity was principally due to host species turnover and to a much lesser degree to nestedness. DTU-host order specificities appear related to trophic or microenvironmental interactions. Conclusions: More rigorous study designs and analyses will be required to discern evolutionary processes and the impact of landscape modification on population dynamics and risk for T. cruzi transmission to humans. |
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Trypanosoma cruzi Nicho (Ecología) Mamíferos Filogenética Enfermedad de chagas Zoogeografía |
author |
Izeta Alberdi, Amaia Doctor autor 15602 Ibarra Cerdeña, Carlos Napoleón autor 13200 Moo Llanes, David Alejandro autor 13403 Ramsey Willoquet, Janine M. Doctora autor 14239 |
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Izeta Alberdi, Amaia Doctor autor 15602 Ibarra Cerdeña, Carlos Napoleón autor 13200 Moo Llanes, David Alejandro autor 13403 Ramsey Willoquet, Janine M. Doctora autor 14239 |
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Izeta Alberdi, Amaia Doctor autor 15602 |
title |
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
title_short |
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
title_full |
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
title_fullStr |
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
title_full_unstemmed |
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages |
title_sort |
geographical, landscape and host associations of trypanosoma cruzi dtus and lineages |
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https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1918-2 |
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AT izetaalberdiamaiadoctorautor15602 geographicallandscapeandhostassociationsoftrypanosomacruzidtusandlineages AT ibarracerdenacarlosnapoleonautor13200 geographicallandscapeandhostassociationsoftrypanosomacruzidtusandlineages AT moollanesdavidalejandroautor13403 geographicallandscapeandhostassociationsoftrypanosomacruzidtusandlineages AT ramseywilloquetjaninemdoctoraautor14239 geographicallandscapeandhostassociationsoftrypanosomacruzidtusandlineages |
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KOHA-OAI-ECOSUR:580372024-07-16T11:27:10ZGeographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages Izeta Alberdi, Amaia Doctor autor 15602 Ibarra Cerdeña, Carlos Napoleón autor 13200 Moo Llanes, David Alejandro autor 13403 Ramsey Willoquet, Janine M. Doctora autor 14239 textengBackground: The evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite's evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published. Methods: The current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analytical variables and results that have given rise to interpretations of putative patterns of genetic diversity and diversification of T. cruzi lineages, discrete typing units (DTUs), and populations, and their associations with hosts, vectors, and geographical distribution that have been interpreted as evidence for parasite subpopulation specificities. Results: Few studies use hypothesis-driven or quantitative analysis for T. cruzi phylogeny (16/58 studies) or phylogeography (10/13). Among these, only one phylogenetic and five phylogeographic studies analyzed molecular markers directly from tissues (i.e. not from isolates). Analysis of T. cruzi DTU or lineage niche and its geographical projection demonstrate extensive sympatry among all clades across the continent and no significant niche differences among DTUs. DTU beta-diversity was high, indicating diverse host assemblages across regions, while host dissimilarity was principally due to host species turnover and to a much lesser degree to nestedness. DTU-host order specificities appear related to trophic or microenvironmental interactions. Conclusions: More rigorous study designs and analyses will be required to discern evolutionary processes and the impact of landscape modification on population dynamics and risk for T. cruzi transmission to humans.Background: The evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite's evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published. Methods: The current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analytical variables and results that have given rise to interpretations of putative patterns of genetic diversity and diversification of T. cruzi lineages, discrete typing units (DTUs), and populations, and their associations with hosts, vectors, and geographical distribution that have been interpreted as evidence for parasite subpopulation specificities. Results: Few studies use hypothesis-driven or quantitative analysis for T. cruzi phylogeny (16/58 studies) or phylogeography (10/13). Among these, only one phylogenetic and five phylogeographic studies analyzed molecular markers directly from tissues (i.e. not from isolates). Analysis of T. cruzi DTU or lineage niche and its geographical projection demonstrate extensive sympatry among all clades across the continent and no significant niche differences among DTUs. DTU beta-diversity was high, indicating diverse host assemblages across regions, while host dissimilarity was principally due to host species turnover and to a much lesser degree to nestedness. DTU-host order specificities appear related to trophic or microenvironmental interactions. Conclusions: More rigorous study designs and analyses will be required to discern evolutionary processes and the impact of landscape modification on population dynamics and risk for T. cruzi transmission to humans.Adobe Acrobat profesional 6.0 o superiorTrypanosoma cruziNicho (Ecología)MamíferosFilogenéticaEnfermedad de chagasZoogeografíaDisponible en líneaParasites & Vectorshttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1918-2Acceso en línea sin restricciones |