Role of thyroid hormones-induced oxidative stress on cardiovascular physiology
Abstract: Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
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Elsevier
2022
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Subjects: | HIPERTIROIDISMO, DISFUNCION CARDIACA, ANTIOXIDANTES, ESTRES OXIDATIVO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/16474 |
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oai:ucacris:123456789-164742023-11-23T17:50:52Z Role of thyroid hormones-induced oxidative stress on cardiovascular physiology Barreiro Arcos, María Laura HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO Abstract: Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism. 2023-06-06T10:59:24Z 2023-06-06T10:59:24Z 2022 Artículo Barreiro Arcos, M. L. Role of thyroid hormones-induced oxidative stress on cardiovascular physiology [en línea]. Biochimica et biophysica Acta. Temas generales. 2022, 1866 (12). doi: 10.1016/j.bbagen.2022.130239. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16474 0304-4165 (impreso) 1872-8006 (online) https://repositorio.uca.edu.ar/handle/123456789/16474 10.1016/j.bbagen.2022.130239 36064072 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Biochimica et biophysica Acta. Temas generales Vol.1866, No.12, 2022 |
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HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO |
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HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO Barreiro Arcos, María Laura Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
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Abstract: Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are
involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance,
and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target
genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain
intracellular pathways involved in the preservation of the structure and functionality of the heart, causing
relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular
system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the
antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we
analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac
dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed
during hyperthyroidism. |
format |
Artículo |
topic_facet |
HIPERTIROIDISMO DISFUNCION CARDIACA ANTIOXIDANTES ESTRES OXIDATIVO |
author |
Barreiro Arcos, María Laura |
author_facet |
Barreiro Arcos, María Laura |
author_sort |
Barreiro Arcos, María Laura |
title |
Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
title_short |
Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
title_full |
Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
title_fullStr |
Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
title_full_unstemmed |
Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
title_sort |
role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://repositorio.uca.edu.ar/handle/123456789/16474 |
work_keys_str_mv |
AT barreiroarcosmarialaura roleofthyroidhormonesinducedoxidativestressoncardiovascularphysiology |
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1787224528161603584 |