Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.
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Elsevier
2017
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Subjects: | ESTRES PRENATAL, MEMORIA ESPACIAL, NEUROTROFINAS, CORTICOSTERONA, TRASTORNOS DE LA MEMORIA, EMBARAZO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/14598 |
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oai:ucacris:123456789-145982024-03-21T16:07:31Z Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress Pascuan, C.G. Di Rosso, M. E. Pivoz-Avedikian, J.E. Wald, Miriam Ruth Zorrilla Zubilete, M.A. Genaro, Ana María ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress. 2022-08-02T15:38:33Z 2022-08-02T15:38:33Z 2017 Artículo Pascuan, C.G. et al. Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress [en línea]. Physiology & Behavior. 2017, 173. doi: 10.1016/j.physbeh.2017.01.045. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14598 0031-9384 1873-507X (online) https://repositorio.uca.edu.ar/handle/123456789/14598 10.1016/j.physbeh.2017.01.045 28167147 eng Acceso restringido http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Physiology & Behavior Vol.173, 2017 |
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ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO |
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ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO Pascuan, C.G. Di Rosso, M. E. Pivoz-Avedikian, J.E. Wald, Miriam Ruth Zorrilla Zubilete, M.A. Genaro, Ana María Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
description |
Abstract:ESTRÉS PRENATAL
Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress. |
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Artículo |
topic_facet |
ESTRES PRENATAL MEMORIA ESPACIAL NEUROTROFINAS CORTICOSTERONA TRASTORNOS DE LA MEMORIA EMBARAZO |
author |
Pascuan, C.G. Di Rosso, M. E. Pivoz-Avedikian, J.E. Wald, Miriam Ruth Zorrilla Zubilete, M.A. Genaro, Ana María |
author_facet |
Pascuan, C.G. Di Rosso, M. E. Pivoz-Avedikian, J.E. Wald, Miriam Ruth Zorrilla Zubilete, M.A. Genaro, Ana María |
author_sort |
Pascuan, C.G. |
title |
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
title_short |
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
title_full |
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
title_fullStr |
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
title_full_unstemmed |
Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
title_sort |
alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress |
publisher |
Elsevier |
publishDate |
2017 |
url |
https://repositorio.uca.edu.ar/handle/123456789/14598 |
work_keys_str_mv |
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