Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents
Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations. Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE). Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP. Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.
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Elsevier
2019
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Subjects: | ESTRES PRENATAL, SINDROME METABOLICO, HORMONAS, PRESION SANGUINEA, PESO AL NACER, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/10053 |
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oai:ucacris:123456789-100532024-03-12T10:41:40Z Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents Burgueño, Adriana Laura Juárez, Yamila R. Genaro, Ana María Tellechea, Mariana L. ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations. Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE). Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP. Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS. 2020-05-21T22:54:36Z 2020-05-21T22:54:36Z 2019 Artículo Burgueño, A. L., et al. Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents [en línea]. Postprint de artículo publicado en Psychoneuroendocrinology. 2019, 113. doi:10.1016/j.psyneuen.2019.104560. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10053 0306-4530 (online) https://repositorio.uca.edu.ar/handle/123456789/10053 10.1016/j.psyneuen.2019.104560 eng Acceso abierto. 12 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Psychoneuroendocrinology. 2019, 113. |
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ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER |
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ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER Burgueño, Adriana Laura Juárez, Yamila R. Genaro, Ana María Tellechea, Mariana L. Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
description |
Abstract: Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility
to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was
to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by
body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and
blood lipid concentrations.
Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using
random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2)
during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid
excess (PCE).
Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported
in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting
in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring
adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased
SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS
on SBP.
Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids,
but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available
evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps.
This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional
studies should address the association with MS. |
format |
Artículo |
topic_facet |
ESTRES PRENATAL SINDROME METABOLICO HORMONAS PRESION SANGUINEA PESO AL NACER |
author |
Burgueño, Adriana Laura Juárez, Yamila R. Genaro, Ana María Tellechea, Mariana L. |
author_facet |
Burgueño, Adriana Laura Juárez, Yamila R. Genaro, Ana María Tellechea, Mariana L. |
author_sort |
Burgueño, Adriana Laura |
title |
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
title_short |
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
title_full |
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
title_fullStr |
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
title_full_unstemmed |
Prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
title_sort |
prenatal stress and later metabolic consequences : systematic review and meta-analysis in rodents |
publisher |
Elsevier |
publishDate |
2019 |
url |
https://repositorio.uca.edu.ar/handle/123456789/10053 |
work_keys_str_mv |
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_version_ |
1794795101771268096 |