In search of essentiality: Mollicute-specific genes shared by twelve genomes

Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.

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Main Authors: Souza,Rangel Celso, Almeida,Darcy Fontoura de, Zaha,Arnaldo, Morais,David Anderson de Lima, Vasconcelos,Ana Tereza Ribeiro de
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Genética 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200002
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spelling oai:scielo:S1415-475720070002000022007-05-14In search of essentiality: Mollicute-specific genes shared by twelve genomesSouza,Rangel CelsoAlmeida,Darcy Fontoura deZaha,ArnaldoMorais,David Anderson de LimaVasconcelos,Ana Tereza Ribeiro de mollicutes comparative genomics synteny bidirectional best hit Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.info:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaGenetics and Molecular Biology v.30 n.1 suppl.0 20072007-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200002en10.1590/S1415-47572007000200002
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author Souza,Rangel Celso
Almeida,Darcy Fontoura de
Zaha,Arnaldo
Morais,David Anderson de Lima
Vasconcelos,Ana Tereza Ribeiro de
spellingShingle Souza,Rangel Celso
Almeida,Darcy Fontoura de
Zaha,Arnaldo
Morais,David Anderson de Lima
Vasconcelos,Ana Tereza Ribeiro de
In search of essentiality: Mollicute-specific genes shared by twelve genomes
author_facet Souza,Rangel Celso
Almeida,Darcy Fontoura de
Zaha,Arnaldo
Morais,David Anderson de Lima
Vasconcelos,Ana Tereza Ribeiro de
author_sort Souza,Rangel Celso
title In search of essentiality: Mollicute-specific genes shared by twelve genomes
title_short In search of essentiality: Mollicute-specific genes shared by twelve genomes
title_full In search of essentiality: Mollicute-specific genes shared by twelve genomes
title_fullStr In search of essentiality: Mollicute-specific genes shared by twelve genomes
title_full_unstemmed In search of essentiality: Mollicute-specific genes shared by twelve genomes
title_sort in search of essentiality: mollicute-specific genes shared by twelve genomes
description Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.
publisher Sociedade Brasileira de Genética
publishDate 2007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200002
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