In search of essentiality: Mollicute-specific genes shared by twelve genomes
Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.
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Sociedade Brasileira de Genética
2007
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oai:scielo:S1415-475720070002000022007-05-14In search of essentiality: Mollicute-specific genes shared by twelve genomesSouza,Rangel CelsoAlmeida,Darcy Fontoura deZaha,ArnaldoMorais,David Anderson de LimaVasconcelos,Ana Tereza Ribeiro de mollicutes comparative genomics synteny bidirectional best hit Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium.info:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaGenetics and Molecular Biology v.30 n.1 suppl.0 20072007-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200002en10.1590/S1415-47572007000200002 |
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Souza,Rangel Celso Almeida,Darcy Fontoura de Zaha,Arnaldo Morais,David Anderson de Lima Vasconcelos,Ana Tereza Ribeiro de |
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Souza,Rangel Celso Almeida,Darcy Fontoura de Zaha,Arnaldo Morais,David Anderson de Lima Vasconcelos,Ana Tereza Ribeiro de In search of essentiality: Mollicute-specific genes shared by twelve genomes |
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Souza,Rangel Celso Almeida,Darcy Fontoura de Zaha,Arnaldo Morais,David Anderson de Lima Vasconcelos,Ana Tereza Ribeiro de |
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Souza,Rangel Celso |
title |
In search of essentiality: Mollicute-specific genes shared by twelve genomes |
title_short |
In search of essentiality: Mollicute-specific genes shared by twelve genomes |
title_full |
In search of essentiality: Mollicute-specific genes shared by twelve genomes |
title_fullStr |
In search of essentiality: Mollicute-specific genes shared by twelve genomes |
title_full_unstemmed |
In search of essentiality: Mollicute-specific genes shared by twelve genomes |
title_sort |
in search of essentiality: mollicute-specific genes shared by twelve genomes |
description |
Mollicutes are cell wall-less bacteria with a genome characterized by its small size. Chromosomal rearrangements help these organisms evade host immune surveillance and hence cause disease. Our goal was to determine genes shared by Mollicutes genomes using the bidirectional best hit methodology. The twelve studied Mollicutes share 210 genes, most of which (> 60%) fall into the following COG categories: translation, ribosomal structure and biogenesis; DNA replication, recombination and repair; nucleotide transport and metabolism and energy production and conversion. Thirty Mollicute-specific genes were identified, 22 of them previously described as essential genes in Mycoplasma genitalium. |
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Sociedade Brasileira de Genética |
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2007 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200002 |
work_keys_str_mv |
AT souzarangelcelso insearchofessentialitymollicutespecificgenessharedbytwelvegenomes AT almeidadarcyfontourade insearchofessentialitymollicutespecificgenessharedbytwelvegenomes AT zahaarnaldo insearchofessentialitymollicutespecificgenessharedbytwelvegenomes AT moraisdavidandersondelima insearchofessentialitymollicutespecificgenessharedbytwelvegenomes AT vasconcelosanaterezaribeirode insearchofessentialitymollicutespecificgenessharedbytwelvegenomes |
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1756419001872809984 |