Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients
ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.
Main Authors: | , , , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Brazilian Society of Infectious Diseases
2017
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600606 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1413-86702017000600606 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1413-867020170006006062017-12-11Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patientsPassos,Ana Isabela MorschDertkigil,Rachel PoloRamos,Marcelo de CarvalhoBusso-Lopes,Ariane FidelisTararan,CibeleRibeiro,Erivan OlindaSchreiber,Angélica ZaninelliTrabasso,PlinioResende,Mariangela RibeiroMoretti,Maria Luiza Pulmonary infection HIV/AIDS (1-3)-β-D-Glugan LDH LAMP Pneumocystosis Fungal infection ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.info:eu-repo/semantics/openAccessBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious Diseases v.21 n.6 20172017-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600606en10.1016/j.bjid.2017.07.002 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Passos,Ana Isabela Morsch Dertkigil,Rachel Polo Ramos,Marcelo de Carvalho Busso-Lopes,Ariane Fidelis Tararan,Cibele Ribeiro,Erivan Olinda Schreiber,Angélica Zaninelli Trabasso,Plinio Resende,Mariangela Ribeiro Moretti,Maria Luiza |
spellingShingle |
Passos,Ana Isabela Morsch Dertkigil,Rachel Polo Ramos,Marcelo de Carvalho Busso-Lopes,Ariane Fidelis Tararan,Cibele Ribeiro,Erivan Olinda Schreiber,Angélica Zaninelli Trabasso,Plinio Resende,Mariangela Ribeiro Moretti,Maria Luiza Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
author_facet |
Passos,Ana Isabela Morsch Dertkigil,Rachel Polo Ramos,Marcelo de Carvalho Busso-Lopes,Ariane Fidelis Tararan,Cibele Ribeiro,Erivan Olinda Schreiber,Angélica Zaninelli Trabasso,Plinio Resende,Mariangela Ribeiro Moretti,Maria Luiza |
author_sort |
Passos,Ana Isabela Morsch |
title |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
title_short |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
title_full |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
title_fullStr |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
title_full_unstemmed |
Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients |
title_sort |
serum markers as an aid in the diagnosis of pulmonary fungal infections in aids patients |
description |
ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population. |
publisher |
Brazilian Society of Infectious Diseases |
publishDate |
2017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600606 |
work_keys_str_mv |
AT passosanaisabelamorsch serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT dertkigilrachelpolo serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT ramosmarcelodecarvalho serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT bussolopesarianefidelis serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT tararancibele serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT ribeiroerivanolinda serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT schreiberangelicazaninelli serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT trabassoplinio serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT resendemariangelaribeiro serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients AT morettimarialuiza serummarkersasanaidinthediagnosisofpulmonaryfungalinfectionsinaidspatients |
_version_ |
1756416549596430336 |