Differential diagnosis between glomus tumor and carcinoid of the stomach

We report a rare case of gastric glomus tumor with preoperative diagnosis of carcinoid tumor in a 57-year-old man. Immunophenotyping panel revealed expression of smooth muscle actin and vimentin by tumor cells with pericellular collagen IV and absence of expression of neuroendocrine makers. Recent advances on diagnosis of gastric glomus tumor and understanding of its biological behaviour is reviewed. This case highlights the overlapping features of gastric glomus tumor and carcinoid suggesting that immunohistochemistry should be considered for this differential diagnosis in all cases.

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Bibliographic Details
Main Authors: Athanazio,D. A., Motta,M. P., Motta,A., Studart,E., Athanazio,P. R. F.
Format: Digital revista
Language:English
Published: Sociedade Portuguesa de Gastrenterologia 2009
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782009000100004
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Summary:We report a rare case of gastric glomus tumor with preoperative diagnosis of carcinoid tumor in a 57-year-old man. Immunophenotyping panel revealed expression of smooth muscle actin and vimentin by tumor cells with pericellular collagen IV and absence of expression of neuroendocrine makers. Recent advances on diagnosis of gastric glomus tumor and understanding of its biological behaviour is reviewed. This case highlights the overlapping features of gastric glomus tumor and carcinoid suggesting that immunohistochemistry should be considered for this differential diagnosis in all cases.