Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
The aim of this study was to evaluate histologically the effect of two biomaterials, a biomaterial derived from porcine Urinary submucosa Bladder Matrix (UBM) and beta-TriCalcium Phosphate (ß-TCP), on bone defects. Twenty male New Zealand rabbits were used; the models were divided in two groups: the UBM group; the ß-TCP group, and a Negative Control (NC) group. Five-mm defects were created in the femur of each model and then the different biomaterials were set in place depending on each group. At 4 and 8 weeks, the animals in the models were sacrificed and samples of the defect site were collected to perform a Hematoxylin and Eosin stain (H&E). Histologically, ß-TCP group at 4 and 8 weeks presented neoformation of bone-like and cartilage-like tissue, with the presence of inflammatory infiltrate; at 4 and 8 weeks, the UBM group presented neoformation of bone-like and cartilage-like tissue with a low presence of inflammatory infiltrate, and the NC group presented the formation of connective tissue and, in a low proportion, neoformation of bone tissue and cartilage. Both biomaterials, UBM and ß-TCP, exhibited the capacity to promote bone neoformation; however, the UBM-based biomaterial produced a better-organized tissue with a lower inflammatory response compared with the ß-TCP group.
Main Authors: | Muñoz-Ruíz,Abraham, Silva-Benítez,Erika, Soto-Sainz,Eduardo, Cerda-Cristerna,Bernardino, Ortiz-Magdaleno,Mariné, Pozos-Guillen,Amaury, Flores,Héctor |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedad Chilena de Anatomía
2017
|
Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300003 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Alpha-tricalcium phosphate cement in the reconstruction of bone defects in rats
by: Pinto,João Gabriel Souza, et al.
Published: (2011) -
The action of demineralized bovine bone matrix on bone neoformation in rats submitted to experimental alcoholism
by: Buchaim,R.L., et al.
Published: (2013) -
In situ Synchrotron X-ray Powder Diffraction Study of the Early Hydration of α-tricalcium Phosphate/tricalcium Silicate Composite Bone Cement
by: Morejón-Alonso,Loreley, et al.
Published: (2015) -
Decellularized Wharton’s Jelly: Biomaterial Potential for Regenerative Medicine Applications - A Mini-Review
by: Gamba,Luize Kremer, et al.
Published: (2023) -
β-Tricalcium phosphate shaped by replica method
by: Porsani,N. K., et al.
Published: (2019)