Expression of Mmp-20 in Dental Germs of Human Fetus

Expression of Mmp-20 in Dental Germs of Human Fetus

During experiments in animal studies, it has been observed that enamelysin (MMP-20) is expressed during tooth development in the late secretory stage of amelogenesis but not in the mature enamel.The aim of this research was to determine the location of MMP-20 in human tooth germs in the different structures of the enamel organ.The detection of MMP-20 was performed by immunohistochemistry in 20 specimens obtained from human fetuses. Immunostaining of MMP-20 was observed from the presecretor stadium in stellate reticulum and intermediate stratum and in the basal portion of ameloblasts in the secretory stage in stellate reticulum, stratum intermedium, secretory ameloblasts, odontoblasts and dental papilla. The results of this research show the location of MMP-20 in tooth germ development in humans and provides the foundation for future research about the process of dental organ formation.

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Bibliographic Details
Main Authors: Gutiérrez Cantú,Francisco Javier, Mariel Cárdenas,Jairo, Oliva Rodríguez,Ricardo, Romo Ramírez,Gabriel Fernando, Sánchez Méraz,Wulfrano, Mariel Murga,Humberto, Leal Tobias,Luis Armando
Format: Digital revista
Language:English
Published: Sociedad Chilena de Anatomía 2014
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400022
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Summary:During experiments in animal studies, it has been observed that enamelysin (MMP-20) is expressed during tooth development in the late secretory stage of amelogenesis but not in the mature enamel.The aim of this research was to determine the location of MMP-20 in human tooth germs in the different structures of the enamel organ.The detection of MMP-20 was performed by immunohistochemistry in 20 specimens obtained from human fetuses. Immunostaining of MMP-20 was observed from the presecretor stadium in stellate reticulum and intermediate stratum and in the basal portion of ameloblasts in the secretory stage in stellate reticulum, stratum intermedium, secretory ameloblasts, odontoblasts and dental papilla. The results of this research show the location of MMP-20 in tooth germ development in humans and provides the foundation for future research about the process of dental organ formation.

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