Effect of the mixing method on the sustained release profile of pelanserin from HPMC / citric acid matrix tablets
Matrices obtained by wet granulation, containing variable citric acid quantities and employing the model: Mt / Minf = k tn, showed greater release constants (k av = 0.236) and exponent n values (n av = 0.736) than those obtained by mixing in the dry (tumbling mixing), k av = 0.185 and n av = 0.606. This indicates a greater tendency to a relaxation/erosion release mechanism of wet granulation compared to dry mixing. The results are attributed to changes in the citric acid distribution.
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| Main Authors: | , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2003
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0583-76932003000100013 |
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| Summary: | Matrices obtained by wet granulation, containing variable citric acid quantities and employing the model: Mt / Minf = k tn, showed greater release constants (k av = 0.236) and exponent n values (n av = 0.736) than those obtained by mixing in the dry (tumbling mixing), k av = 0.185 and n av = 0.606. This indicates a greater tendency to a relaxation/erosion release mechanism of wet granulation compared to dry mixing. The results are attributed to changes in the citric acid distribution. |
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