Synthesis and preliminary biological evaluation of two new cacalol esters of Naproxen and Ibuprofen
The successful synthesis of two propionates Naproxen and Ibuprofen of the tricyclic terpenic phenol cacalol (Naproxen-cacalol and Ibuprofen-cacalol) is reported. Their NMR data, preliminary anti-inflammatory and analgesic evaluations, and molecular modelling are described.
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| Main Authors: | , , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Laboratorios Mixim S.A.
2012
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0370-59432012000200006 |
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| Summary: | The successful synthesis of two propionates Naproxen and Ibuprofen of the tricyclic terpenic phenol cacalol (Naproxen-cacalol and Ibuprofen-cacalol) is reported. Their NMR data, preliminary anti-inflammatory and analgesic evaluations, and molecular modelling are described. |
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