Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains.

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Bibliographic Details
Main Authors: Ávila,Fábio N., Pinto,Francisco C. L., Sousa,Thiciana S., Torres,Maria Conceição M., Costa-Lotufo,Leticia V., Rocha,Danilo D., Vasconcelos,Mayron A. de, Cardoso-Sá,Nairley, Teixeira,Edson H., Albuquerque,Maria Rose Jane R., Silveira,Edilberto R., Pessoa,Otília D. L.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601014
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Summary:Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains.

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