Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats
PURPOSE: To evaluate the effect of ischemic postconditioning (IPC) on intestinal mucosa of rats subjected to ischemia and reperfusion process comparing two cycles of reperfusion and ischemia lasting two minutes each and four cycles of reperfusion and ischemia lasting 30 seconds each METHODS: Thirty Wistar rats were distributed into three groups: group A (10 rats), ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion plus IPC by two lasting two minutes each; and Group C (10 rats), ischemia and reperfusion plus IPC by four cycles lasting 30 seconds each. Finally, a segment of small intestine was resected for histological analysis. We analysed the results according to Chiu et al . classification and proceeded to the statistical treatment by Kruskal-Wallis test (p<0.05). RESULTS: The mean degree of tissue injury according to Chiu et al . classification were: Group A, 2.77; in group B, 1.4; and group C, 1.4. B X C (p<0.05). CONCLUSIONS: Ischemic postconditioning was able to minimize reperfusion injury of rats undergone mesenteric ischemia and reperfusion process. There was no difference in the effectiveness of the method comparing two cycles of two minutes with four cycles of 30 seconds by H&E histological evaluation of the ileum after 60-minute reperfusion.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2015
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oai:scielo:S0102-865020150010007092016-01-05Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in ratsSantos,Carlos Henrique Marques dosAydos,Ricardo DutraNogueira Neto,EdMiiji,Luciana Nakao OdashiroCassino,Pedro CarvalhoAhmed,Isadora IshaqCalheiros,Nadia MeneguessoGarcia,MilenaSilva,Anderson Fernandes da Ischemic Postconditioning Ischemia Reperfusion Intestines Rats PURPOSE: To evaluate the effect of ischemic postconditioning (IPC) on intestinal mucosa of rats subjected to ischemia and reperfusion process comparing two cycles of reperfusion and ischemia lasting two minutes each and four cycles of reperfusion and ischemia lasting 30 seconds each METHODS: Thirty Wistar rats were distributed into three groups: group A (10 rats), ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion plus IPC by two lasting two minutes each; and Group C (10 rats), ischemia and reperfusion plus IPC by four cycles lasting 30 seconds each. Finally, a segment of small intestine was resected for histological analysis. We analysed the results according to Chiu et al . classification and proceeded to the statistical treatment by Kruskal-Wallis test (p<0.05). RESULTS: The mean degree of tissue injury according to Chiu et al . classification were: Group A, 2.77; in group B, 1.4; and group C, 1.4. B X C (p<0.05). CONCLUSIONS: Ischemic postconditioning was able to minimize reperfusion injury of rats undergone mesenteric ischemia and reperfusion process. There was no difference in the effectiveness of the method comparing two cycles of two minutes with four cycles of 30 seconds by H&E histological evaluation of the ileum after 60-minute reperfusion.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.30 n.10 20152015-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015001000709en10.1590/S0102-865020150100000009 |
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Santos,Carlos Henrique Marques dos Aydos,Ricardo Dutra Nogueira Neto,Ed Miiji,Luciana Nakao Odashiro Cassino,Pedro Carvalho Ahmed,Isadora Ishaq Calheiros,Nadia Meneguesso Garcia,Milena Silva,Anderson Fernandes da |
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Santos,Carlos Henrique Marques dos Aydos,Ricardo Dutra Nogueira Neto,Ed Miiji,Luciana Nakao Odashiro Cassino,Pedro Carvalho Ahmed,Isadora Ishaq Calheiros,Nadia Meneguesso Garcia,Milena Silva,Anderson Fernandes da Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
author_facet |
Santos,Carlos Henrique Marques dos Aydos,Ricardo Dutra Nogueira Neto,Ed Miiji,Luciana Nakao Odashiro Cassino,Pedro Carvalho Ahmed,Isadora Ishaq Calheiros,Nadia Meneguesso Garcia,Milena Silva,Anderson Fernandes da |
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Santos,Carlos Henrique Marques dos |
title |
Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
title_short |
Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
title_full |
Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
title_fullStr |
Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
title_full_unstemmed |
Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats |
title_sort |
importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. experimental study in rats |
description |
PURPOSE: To evaluate the effect of ischemic postconditioning (IPC) on intestinal mucosa of rats subjected to ischemia and reperfusion process comparing two cycles of reperfusion and ischemia lasting two minutes each and four cycles of reperfusion and ischemia lasting 30 seconds each METHODS: Thirty Wistar rats were distributed into three groups: group A (10 rats), ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion plus IPC by two lasting two minutes each; and Group C (10 rats), ischemia and reperfusion plus IPC by four cycles lasting 30 seconds each. Finally, a segment of small intestine was resected for histological analysis. We analysed the results according to Chiu et al . classification and proceeded to the statistical treatment by Kruskal-Wallis test (p<0.05). RESULTS: The mean degree of tissue injury according to Chiu et al . classification were: Group A, 2.77; in group B, 1.4; and group C, 1.4. B X C (p<0.05). CONCLUSIONS: Ischemic postconditioning was able to minimize reperfusion injury of rats undergone mesenteric ischemia and reperfusion process. There was no difference in the effectiveness of the method comparing two cycles of two minutes with four cycles of 30 seconds by H&E histological evaluation of the ileum after 60-minute reperfusion. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015001000709 |
work_keys_str_mv |
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