Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients
PURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2012
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oai:scielo:S0102-865020120010000092012-09-27Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patientsCruz,Sylvia Heloisa ArantesNadal,Sidney RobertoNadal,Carmen Ruth ManzioneCalore,Edenilson Eduardo Acquired Immunodeficiency Syndrome Carcinoma, Squamous Cell Anal Canal HIV Langerhans Cells PURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.27 n.10 20122012-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009en10.1590/S0102-86502012001000009 |
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Cruz,Sylvia Heloisa Arantes Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo |
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Cruz,Sylvia Heloisa Arantes Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
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Cruz,Sylvia Heloisa Arantes Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo |
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Cruz,Sylvia Heloisa Arantes |
title |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_short |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_full |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_fullStr |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_full_unstemmed |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_sort |
evaluation of langerhans cells counts comparing hiv-positive and negative anal squamous cell-carcinoma patients |
description |
PURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009 |
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