Reversed phase HPLC determination of tamoxifen in dog plasma and its pharmaco-kinetics after a single oral dose administration
The analytical method developed to evaluate tamoxifen in dog plasma samples was precise, accurate, robust and linear in the range of 5-200 ng/mL. The limits of detection and quantification were 0.981 ng/mL and 2.97 ng/mL, respectively. Besides, the intra-day precision and accuracy variations were 8.78 and 10.16%, respectively. Tamoxifen concentrations were analyzed by combined reversed phase liquid chromatography and UV detection (lambda=280 nm). The study was conducted using an open randomized 2-period crossover balanced design with a 1-week washout period between the doses. This simple, rapid and selective method is suitable for pharmacokinetic, bioavailability and bioequivalence studies.
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Main Authors: | Santana,Davi Pereira de, Braga,Rossana Maria Carvalho, Strattmman,Ruth, Albuquerque,Miracy Muniz, Bedor,Danilo César Galindo, Leal,Leila Bastos, Silva,José Alexsandro da |
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Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Química
2008
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000100010 |
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