Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers

Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers

ABSTRACT Background: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. Methods: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylation in the central nervous system was evaluated. Results: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains. Conclusions: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains.

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Main Authors: Santos,Sergio Vieira dos, Fortuna,Giulio de los Santos, Barbosa,Lariane Monteiro, Meireles,Luciana Regina, Tiago,Érico Silva, Chieffi,Pedro Paulo
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100631
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spelling oai:scielo:S0037-868220220001006312022-10-21Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markersSantos,Sergio Vieira dosFortuna,Giulio de los SantosBarbosa,Lariane MonteiroMeireles,Luciana ReginaTiago,Érico SilvaChieffi,Pedro Paulo Toxoplasma gondii ME49 and VEG strains Rattus norvegicus Behavior alterations Arginine-vasopressin promoter gene ABSTRACT Background: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. Methods: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylation in the central nervous system was evaluated. Results: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains. Conclusions: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.55 20222022-01-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100631en10.1590/0037-8682-0122-2022
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country Brasil
countrycode BR
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Santos,Sergio Vieira dos
Fortuna,Giulio de los Santos
Barbosa,Lariane Monteiro
Meireles,Luciana Regina
Tiago,Érico Silva
Chieffi,Pedro Paulo
spellingShingle Santos,Sergio Vieira dos
Fortuna,Giulio de los Santos
Barbosa,Lariane Monteiro
Meireles,Luciana Regina
Tiago,Érico Silva
Chieffi,Pedro Paulo
Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
author_facet Santos,Sergio Vieira dos
Fortuna,Giulio de los Santos
Barbosa,Lariane Monteiro
Meireles,Luciana Regina
Tiago,Érico Silva
Chieffi,Pedro Paulo
author_sort Santos,Sergio Vieira dos
title Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_short Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_full Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_fullStr Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_full_unstemmed Evaluation of aversive behavior in Rattus norvegicus experimentally infected by two distinct strains of Toxoplasma gondii (ME49 and VEG): study of epigenetic markers
title_sort evaluation of aversive behavior in rattus norvegicus experimentally infected by two distinct strains of toxoplasma gondii (me49 and veg): study of epigenetic markers
description ABSTRACT Background: Behavioral changes in Rattus norvegicus infected with two strains of Toxoplasma gondii (ME49 and VEG) were investigated. Methods: Rats were evaluated for motor activity and aversion or attraction to cat urine 60 days after infection. After euthanasia, arginine-vasopressin gene methylation in the central nervous system was evaluated. Results: A significant difference was observed in the methylation of the arginine-vasopressin promoter gene between rats infected with the ME49 and VEG strains. Conclusions: Although differences were not observed in many parameters, significant differences were observed in the methylation of the arginine-vasopressin promoter gene in rats infected with the two studied strains.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100631
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