Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil
Abstract INTRODUCTION We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious disease referral center. Changes in patient profiles over time were also evaluated. METHODS This retrospective study included patients with CD from November 1986-December 2019. All patients underwent an evaluation protocol that included sociodemographic profile; epidemiological history; anamnesis; and physical, cardiologic, and digestive examinations. Trend differences for each 5-year period from 1986 to 2019 were tested using a nonparametric trend test for continuous and generalized linear models with binomial distribution for categorical variables. RESULTS A total of 2,168 patients (52.2% women) were included, with a mean age of 47.8 years old. White patients with low levels of education predominated. The reported transmission mode was vectorial in 90.2% of cases. The majority came from areas with a high prevalence (52.2%) and morbidity (67.8%) of CD. The most common clinical presentation was the indeterminate form (44.9%). The number of patients referred gradually decreased and the age at admission increased during the study period, as did the patients’ levels of education. CONCLUSIONS The clinical profile of CD is characterized by a predominance of the indeterminate form of the disease. Regarding the patients who were followed up at the referral center, there was a progressive increase in the mean age and a concomitant decrease in the number of new patients. This reflects the successful control of vector and transfusion transmission in Brazil as well as the aging population of patients with CD.
Main Authors: | Hasslocher-Moreno,Alejandro Marcel, Saraiva,Roberto Magalhaes, Brasil,Pedro Emmanuel Alvarenga Americano do, Sangenis,Luiz Henrique Conde, Xavier,Sergio Salles, Sousa,Andréa Silvestre de, Sperandio-da-Silva,Gilberto Marcelo, Mendes,Fernanda de Souza Nogueira Sardinha, Costa,Andréa Rodrigues da, Holanda,Marcelo Teixeira de, Veloso,Henrique Horta, Mazzoli-Rocha,Flavia, Carneiro,Fernanda Martins, Portela,Luciana Fernandes, Mediano,Mauro Felippe Felix |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical - SBMT
2021
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100324 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chagas disease mortality during the coronavirus disease 2019 pandemic: A Brazilian referral center experience
by: Hasslocher-Moreno,Alejandro Marcel, et al.
Published: (2022) -
Cardiac rehabilitation program in patients with Chagas heart failure: a single-arm pilot study
by: Mediano,Mauro Felippe Felix, et al.
Published: (2016) -
Comprehensive care for patients with Chagas cardiomyopathy during the coronavirus disease pandemic
by: Mazzoli-Rocha,Flavia, et al.
Published: (2020) -
Agreement between upper endoscopy and esophagography in the diagnosis of megaesophagus in Chagas disease
by: Barros,Fernando de, et al.
Published: (2019) -
FIRST REPORT OF ACUTE CHAGAS DISEASE BY VECTOR TRANSMISSION IN RIO DE JANEIRO STATE, BRAZIL
by: SANGENIS,Luiz Henrique Conde, et al.
Published: (2015)