Aplasia medular adquirida, experiencia en un hospital público de referencia

Background: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%. Aim: To report the experience with SCT and ATG for AA in a public hospital. Patients and Methods: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up. Results: Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG. Conclusions: SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.

Bibliographic Details

Main Authors:	León,Pilar, Cardemil,Daniela, Osorio,Rocío, Peña,Camila, Valladares,Ximena, Puga,Bárbara, Cabrera,María Elena
Format:	Digital revista
Language:	Spanish / Castilian
Published:	Sociedad Médica de Santiago 2018
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000200175
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