Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality
ABSTRACT Meningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in São Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7–27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients. The cerebrospinal triad: pleocytosis, elevated protein levels and low glucose levels was present in 79% of patients. Factors associated with mortality in the multivariate model were age above 50 years, seizures, tachycardia, hypotension and neck stiffness. The classic clinical and laboratory triads of meningococcal meningitis were variable. The fatality rate was low. Age, seizures and shock signs were independently associated with mortality.
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Academia Brasileira de Neurologia - ABNEURO
2016
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oai:scielo:S0004-282X20160011008752017-02-17Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortalityStrelow,Vanessa L.Miranda,Érique José F. Peixoto deKolbe,Karin R.Framil,Juliana V. SouzaOliveira,Augusto Penalva deVidal,José E. meningitis, meningococcal Neisseria meningitidis epidemiology ABSTRACT Meningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in São Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7–27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients. The cerebrospinal triad: pleocytosis, elevated protein levels and low glucose levels was present in 79% of patients. Factors associated with mortality in the multivariate model were age above 50 years, seizures, tachycardia, hypotension and neck stiffness. The classic clinical and laboratory triads of meningococcal meningitis were variable. The fatality rate was low. Age, seizures and shock signs were independently associated with mortality.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.74 n.11 20162016-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001100875en10.1590/0004-282x20160143 |
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Strelow,Vanessa L. Miranda,Érique José F. Peixoto de Kolbe,Karin R. Framil,Juliana V. Souza Oliveira,Augusto Penalva de Vidal,José E. |
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Strelow,Vanessa L. Miranda,Érique José F. Peixoto de Kolbe,Karin R. Framil,Juliana V. Souza Oliveira,Augusto Penalva de Vidal,José E. Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
author_facet |
Strelow,Vanessa L. Miranda,Érique José F. Peixoto de Kolbe,Karin R. Framil,Juliana V. Souza Oliveira,Augusto Penalva de Vidal,José E. |
author_sort |
Strelow,Vanessa L. |
title |
Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
title_short |
Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
title_full |
Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
title_fullStr |
Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
title_full_unstemmed |
Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
title_sort |
meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality |
description |
ABSTRACT Meningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in São Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7–27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients. The cerebrospinal triad: pleocytosis, elevated protein levels and low glucose levels was present in 79% of patients. Factors associated with mortality in the multivariate model were age above 50 years, seizures, tachycardia, hypotension and neck stiffness. The classic clinical and laboratory triads of meningococcal meningitis were variable. The fatality rate was low. Age, seizures and shock signs were independently associated with mortality. |
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Academia Brasileira de Neurologia - ABNEURO |
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2016 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001100875 |
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