Short-term mortality and prognostic factors related to status epilepticus
Objective Status epilepticus (SE) is associated with significant morbidity and mortality, and there is some controversy concerning predictive indicators of outcome. Our main goal was to determine mortality and to identify factors associated with SE prognosis. Method This prospective study in a tertiary-care university hospital, included 105 patients with epileptic seizures lasting more than 30 minutes. Mortality was defined as death during hospital admission. Results The case-fatality rate was 36.2%, which was higher than in previous studies. In univariate analysis, mortality was associated with age, previous epilepsy, complex focal seizures; etiology, recurrence, and refractoriness of SE; clinical complications, and focal SE. In multivariate analysis, mortality was associated only with presence of clinical complications. Conclusions Mortality associated with SE was higher than reported in previous studies, and was not related to age, specific etiology, or SE duration. In multivariate analysis, mortality was independently related to occurrence of medical complications.
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Academia Brasileira de Neurologia - ABNEURO
2015
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oai:scielo:S0004-282X20150008006702015-07-23Short-term mortality and prognostic factors related to status epilepticusStelzer,Fernando GustavoBustamante,Guilherme de OliveiraSander,HeidiSakamoto,Americo CeikiFernandes,Regina Maria França status epilepticus epilepsy mortality prognosis Objective Status epilepticus (SE) is associated with significant morbidity and mortality, and there is some controversy concerning predictive indicators of outcome. Our main goal was to determine mortality and to identify factors associated with SE prognosis. Method This prospective study in a tertiary-care university hospital, included 105 patients with epileptic seizures lasting more than 30 minutes. Mortality was defined as death during hospital admission. Results The case-fatality rate was 36.2%, which was higher than in previous studies. In univariate analysis, mortality was associated with age, previous epilepsy, complex focal seizures; etiology, recurrence, and refractoriness of SE; clinical complications, and focal SE. In multivariate analysis, mortality was associated only with presence of clinical complications. Conclusions Mortality associated with SE was higher than reported in previous studies, and was not related to age, specific etiology, or SE duration. In multivariate analysis, mortality was independently related to occurrence of medical complications. info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.73 n.8 20152015-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000800670en10.1590/0004-282X20150082 |
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Stelzer,Fernando Gustavo Bustamante,Guilherme de Oliveira Sander,Heidi Sakamoto,Americo Ceiki Fernandes,Regina Maria França |
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Stelzer,Fernando Gustavo Bustamante,Guilherme de Oliveira Sander,Heidi Sakamoto,Americo Ceiki Fernandes,Regina Maria França Short-term mortality and prognostic factors related to status epilepticus |
author_facet |
Stelzer,Fernando Gustavo Bustamante,Guilherme de Oliveira Sander,Heidi Sakamoto,Americo Ceiki Fernandes,Regina Maria França |
author_sort |
Stelzer,Fernando Gustavo |
title |
Short-term mortality and prognostic factors related to status epilepticus |
title_short |
Short-term mortality and prognostic factors related to status epilepticus |
title_full |
Short-term mortality and prognostic factors related to status epilepticus |
title_fullStr |
Short-term mortality and prognostic factors related to status epilepticus |
title_full_unstemmed |
Short-term mortality and prognostic factors related to status epilepticus |
title_sort |
short-term mortality and prognostic factors related to status epilepticus |
description |
Objective Status epilepticus (SE) is associated with significant morbidity and mortality, and there is some controversy concerning predictive indicators of outcome. Our main goal was to determine mortality and to identify factors associated with SE prognosis. Method This prospective study in a tertiary-care university hospital, included 105 patients with epileptic seizures lasting more than 30 minutes. Mortality was defined as death during hospital admission. Results The case-fatality rate was 36.2%, which was higher than in previous studies. In univariate analysis, mortality was associated with age, previous epilepsy, complex focal seizures; etiology, recurrence, and refractoriness of SE; clinical complications, and focal SE. In multivariate analysis, mortality was associated only with presence of clinical complications. Conclusions Mortality associated with SE was higher than reported in previous studies, and was not related to age, specific etiology, or SE duration. In multivariate analysis, mortality was independently related to occurrence of medical complications. |
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Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000800670 |
work_keys_str_mv |
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