MRI findings in the diagnosis and monitoring of rasmussen's encephalitis
Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent - crisis (not controlled). MR studies, in addition to help in diagnosis, may be useful for monitoring metabolic changes and progression of disease in Rasmussen's encephalitis.
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia - ABNEURO
2009
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000500002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0004-282X2009000500002 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0004-282X20090005000022009-10-13MRI findings in the diagnosis and monitoring of rasmussen's encephalitisFaria,Andréia V.Reis,FabianoDabus,Guilherme C.Zanardi,Verônica A.Guerreiro,Marilisa M.Cendes,Fernando Rasmussen's encephalitis MRI spectroscopy epilepsy Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent - crisis (not controlled). MR studies, in addition to help in diagnosis, may be useful for monitoring metabolic changes and progression of disease in Rasmussen's encephalitis.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.67 n.3b 20092009-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000500002en10.1590/S0004-282X2009000500002 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Brasil |
| countrycode |
BR |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-br |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Faria,Andréia V. Reis,Fabiano Dabus,Guilherme C. Zanardi,Verônica A. Guerreiro,Marilisa M. Cendes,Fernando |
| spellingShingle |
Faria,Andréia V. Reis,Fabiano Dabus,Guilherme C. Zanardi,Verônica A. Guerreiro,Marilisa M. Cendes,Fernando MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| author_facet |
Faria,Andréia V. Reis,Fabiano Dabus,Guilherme C. Zanardi,Verônica A. Guerreiro,Marilisa M. Cendes,Fernando |
| author_sort |
Faria,Andréia V. |
| title |
MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| title_short |
MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| title_full |
MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| title_fullStr |
MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| title_full_unstemmed |
MRI findings in the diagnosis and monitoring of rasmussen's encephalitis |
| title_sort |
mri findings in the diagnosis and monitoring of rasmussen's encephalitis |
| description |
Rasmussen's encephalitis is a devastating syndrome of multifocal brain dysfunction and focal seizures. Magnetic resonance (MR) findings, associated with clinical data and electroencephalogram (EEG), may indicate the diagnosis and could be an indicative of prognosis. We studied 5 patients with Rasmussen's encephalitis, assessing clinical history and MR images. All patients had refractory focal seizures with a predominant motor component associated with hemispheric atrophy, that was proportional to severity of disease and neurological deficits in these patients. Gray and white matter abnormal signal on T2 MR images were found in patients who had hemiparesis. It was not related to the duration of the disease but to aggressiveness. MR proton spectroscopy in severe disease showed lactate and choline increase and decreased NAA, reflecting neuronal and axonal loss, gliosis and elevated membrane turnover and recent - crisis (not controlled). MR studies, in addition to help in diagnosis, may be useful for monitoring metabolic changes and progression of disease in Rasmussen's encephalitis. |
| publisher |
Academia Brasileira de Neurologia - ABNEURO |
| publishDate |
2009 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000500002 |
| work_keys_str_mv |
AT fariaandreiav mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis AT reisfabiano mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis AT dabusguilhermec mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis AT zanardiveronicaa mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis AT guerreiromarilisam mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis AT cendesfernando mrifindingsinthediagnosisandmonitoringofrasmussensencephalitis |
| _version_ |
1756374458868695040 |