Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.
Main Authors: | Moreira,Maria Elisabete C., Barcinski,Marcello A. |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Academia Brasileira de Ciências
2004
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Apoptotic mimicry: an altruistic behavior in host/Leishmania interplay
by: Wanderley,J.L.M., et al.
Published: (2005) -
The regulation of apoptotic cell death
by: Amarante-Mendes,G.P., et al.
Published: (1999) -
Rotavirus and reovirus interaction with mouse peritoneal resident phagocytic cells
by: Guimarães,M.A.A.M., et al.
Published: (1997) -
Impact of cell harvesting methods on detection of cell surface proteins and apoptotic markers
by: Nowak-Terpiłowska,A., et al.
Published: (2021) -
Cell-Cell recognition /
by: Symposia of the Society for Experimental Biology (32 : 1978 : Cambridge, Great Britain)
Published: (1978)