Characterization of CD79acy + cells in placentas from ruminants
Previous work carried out to characterise different immune cells in ruminant placentas found strong CD79αcynuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cellpopulation, placentomes collected from cattle, sheep and water buffaloes were examined by im-munohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytesand trophoblast cells. Most CD79αcy+ cells co-expressed placental lactogen or cytokeratin and were CD21 andMHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunologicalrole of these cells cannot be ruled out and it is currently unknown if thefindings des
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| Main Authors: | , , , , |
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| Format: | info:ar-repo/semantics/artículo biblioteca |
| Language: | eng |
| Published: |
Elsevier
2019-11
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| Subjects: | Respuesta Inmunológica, Placenta, Rumiante, Anticuerpos, Embriones Animales, Immune Response, Ruminants, Antibodies, Animal Embryos, |
| Online Access: | https://www.sciencedirect.com/science/article/pii/S0165242719301849 http://hdl.handle.net/20.500.12123/6201 https://doi.org/10.1016/j.vetimm.2019.109942 |
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| Summary: | Previous work carried out to characterise different immune cells in ruminant placentas found strong CD79αcynuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cellpopulation, placentomes collected from cattle, sheep and water buffaloes were examined by im-munohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytesand trophoblast cells. Most CD79αcy+ cells co-expressed placental lactogen or cytokeratin and were CD21 andMHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunologicalrole of these cells cannot be ruled out and it is currently unknown if thefindings des |
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