The distribution of spontaneous mutations on quantitative traits and fitness in Drosophila melanogaster
Starting from a completely homozygous population of Drosophila melanogaster, two groups of 100 inbred lines each were established and maintained for 46 generations, by a single brother-sister mating and two double first cousin matings, respectively. Sternopleural bristle number, wing length and wing width were simultaneously scored in all lines every 4-5 generations. The means of four lines in each group departed significantly from the overall mean and, in each case, this was attributed to a single mutation of relatively large effect on at least one trait (0.3-1.4 environmental standard deviations in absolute value). Further analyses revealed widespread pleiotropy, similar gene action of a given mutation for all traits affected, and predominant additive action. No apparent association was found between the magnitudes of mutational effects on the traits and fitness. However, all recessive mutations were deleterious. The distribution of mutant effects was asymmetrical (positive for bristles and negative for wing measurements). Moreover, these distributions had a high variance and may be leptokurtic, due to the presence of major genes. Estimates of the ratio of new mutational variance to environmental variance ranged within (0.7-3.4) x 10-3, those for wing measurements being generally larger. In agreement with theory, the rate of between-line differentiation was independent of population size.
Main Authors: | Santiago, E., Albornoz, J., Domínguez, A., Toro, M. A., López-Fanjul, C. |
---|---|
Format: | journal article biblioteca |
Language: | English |
Published: |
Oxford University Press
1992
|
Online Access: | http://hdl.handle.net/20.500.12792/4155 http://hdl.handle.net/10261/294576 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The distribution of spontaneous mutations on quantitative traits and fitness in Drosophila melanogaster
by: Santiago, E., et al.
Published: (1992) -
Spontaneous mutation for life-history traits in Drosophila melanogaster
by: Martorell, C., et al.
Published: (1998) -
Spontaneous mutation for life-history traits in Drosophila melanogaster
by: Martorell, C., et al.
Published: (1998) -
The response to artificial selection from new mutations in Drosophila melanogaster
by: Caballero, A., et al.
Published: (1991) -
The response to artificial selection from new mutations in Drosophila melanogaster
by: Caballero, A., et al.
Published: (1991)