Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

6 Páginas.

Saved in:
Bibliographic Details
Main Authors: Polledo, Laura, González, J., Benavides, Julio, Martínez-Fernández, B., Ferreras, Mª del Carmen, García Marín, Juan Francisco
Format: artículo biblioteca
Language:English
Published: Springer 2012
Subjects:Maedi, Visna, Sheep, Encephalitis, Neuropathology, Immunology,
Online Access:http://hdl.handle.net/10261/73109
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-igm-es-10261-73109
record_format koha
spelling dig-igm-es-10261-731092021-04-13T14:53:32Z Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression Polledo, Laura González, J. Benavides, Julio Martínez-Fernández, B. Ferreras, Mª del Carmen García Marín, Juan Francisco Maedi Visna Sheep Encephalitis Neuropathology Immunology 6 Páginas. We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral antigen was detected in perivascular cuffs where CD8+ T cells predominated, but in severe lymphocytic lesions, sparse antigen was identified, and CD8+/CD4+ T cells appeared in a similar proportion in multilayer perivascular sleeves. In histiocytic lesions, vessels were surrounded by macrophages with abundant viral antigen, with CD8+/CD4+ T cells and B cells in the periphery. These results could reflect different stages of virus neuroinvasion and clarify the neuropathogenesis of Visna/maedi encephalitis. Spanish Ministry of Education AGL2007-66874-CO4-04/GAN Junta of Castilla y Leon LE36A12-1 Ministry of Education AP2007-02007 Peer reviewed 2013-03-27T12:03:04Z 2013-03-27T12:03:04Z 2012 artículo http://purl.org/coar/resource_type/c_6501 Journal of Neurovirology 18(6): 532-537 (2012) 1355-0284 http://hdl.handle.net/10261/73109 10.1007/s13365-012-0131-0 en http://dx.doi.org/10.1007/s13365-012-0131-0 open Springer
institution IGM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-igm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IGM España
language English
topic Maedi
Visna
Sheep
Encephalitis
Neuropathology
Immunology
Maedi
Visna
Sheep
Encephalitis
Neuropathology
Immunology
spellingShingle Maedi
Visna
Sheep
Encephalitis
Neuropathology
Immunology
Maedi
Visna
Sheep
Encephalitis
Neuropathology
Immunology
Polledo, Laura
González, J.
Benavides, Julio
Martínez-Fernández, B.
Ferreras, Mª del Carmen
García Marín, Juan Francisco
Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
description 6 Páginas.
format artículo
topic_facet Maedi
Visna
Sheep
Encephalitis
Neuropathology
Immunology
author Polledo, Laura
González, J.
Benavides, Julio
Martínez-Fernández, B.
Ferreras, Mª del Carmen
García Marín, Juan Francisco
author_facet Polledo, Laura
González, J.
Benavides, Julio
Martínez-Fernández, B.
Ferreras, Mª del Carmen
García Marín, Juan Francisco
author_sort Polledo, Laura
title Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
title_short Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
title_full Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
title_fullStr Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
title_full_unstemmed Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
title_sort perivascular inflammatory cells in ovine visna/maedi encephalitis and their possible role in virus infection and lesion progression
publisher Springer
publishDate 2012
url http://hdl.handle.net/10261/73109
work_keys_str_mv AT polledolaura perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
AT gonzalezj perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
AT benavidesjulio perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
AT martinezfernandezb perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
AT ferrerasmadelcarmen perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
AT garciamarinjuanfrancisco perivascularinflammatorycellsinovinevisnamaediencephalitisandtheirpossibleroleinvirusinfectionandlesionprogression
_version_ 1777663918537179136

Similar Items