Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model
5 páginas, 3 figuras, 2 tablas.
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
American Society of Parasitologists
2010
|
| Subjects: | BALB/c mice, Immune-response, Vertical transmission, Bovine neosporosis, Toxoplasma-gondii, Real-time, Fetal survival, Parasite load, IFN-gamma, Gestation, |
| Online Access: | http://hdl.handle.net/10261/64451 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-igm-es-10261-64451 |
|---|---|
| record_format |
koha |
| spelling |
dig-igm-es-10261-644512021-04-13T15:28:27Z Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model López Pérez, I. C. Collantes Fernández, E. Rojo Montejo, S. Navarro Lozano, V. Risco Castillo, V. Pérez Pérez, Valentín Pereira Bueno, J. M. Ortega Mora, Luis M. BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation 5 páginas, 3 figuras, 2 tablas. Neospora caninum is one of the more-efficient transplacentally-transmitted organisms. The goal of the present study was to investigate the pathologic and immunologic changes that occur at the materno-fetal interphase in pregnant BALB/c mice infected with N. caninum at mid-gestation. Parasite DNA was detected in feto-placentary units 3 days post-infection (PI). On day 7 PI, the DNA detection level and parasite burden were significantly higher in the placentas than in the fetuses, which may indicate that the parasite is mainly multiplying in the placenta during the initial infection. In the spleens of infected dams, we observed an increase in IFN-gamma, IL-10, and IL-4. However, only IL-4 was upregulated in placentas from the infected dams; this may enhance susceptibility to N. caninum at the materno-fetal interphase and favor transmission to the progeny. Finally, an increase in TNF-alpha expression in nested-PCR-positive placentas combined with necrosis may compromise the viability of the fetuses. This work has been supported by a grant from the Spanish Government (AGL2001-1362). Inmaculada C. López-Pérez has been financed by the Spanish Ministry of Education and Science. This experiment complied with the current local animal protection laws of the European Union. Peer reviewed 2013-01-18T11:58:57Z 2013-01-18T11:58:57Z 2010 artículo http://purl.org/coar/resource_type/c_6501 Journal of Parasitology 96 (5) : 1017-1020 (2010) 0022-3395 http://hdl.handle.net/10261/64451 10.1645/GE-2347.1 en http://dx.doi.org/10.1645/GE-2347.1 open American Society of Parasitologists |
| institution |
IGM ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-igm-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IGM España |
| language |
English |
| topic |
BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation |
| spellingShingle |
BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation López Pérez, I. C. Collantes Fernández, E. Rojo Montejo, S. Navarro Lozano, V. Risco Castillo, V. Pérez Pérez, Valentín Pereira Bueno, J. M. Ortega Mora, Luis M. Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| description |
5 páginas, 3 figuras, 2 tablas. |
| format |
artículo |
| topic_facet |
BALB/c mice Immune-response Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation |
| author |
López Pérez, I. C. Collantes Fernández, E. Rojo Montejo, S. Navarro Lozano, V. Risco Castillo, V. Pérez Pérez, Valentín Pereira Bueno, J. M. Ortega Mora, Luis M. |
| author_facet |
López Pérez, I. C. Collantes Fernández, E. Rojo Montejo, S. Navarro Lozano, V. Risco Castillo, V. Pérez Pérez, Valentín Pereira Bueno, J. M. Ortega Mora, Luis M. |
| author_sort |
López Pérez, I. C. |
| title |
Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| title_short |
Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| title_full |
Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| title_fullStr |
Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| title_full_unstemmed |
Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| title_sort |
effects of neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
| publisher |
American Society of Parasitologists |
| publishDate |
2010 |
| url |
http://hdl.handle.net/10261/64451 |
| work_keys_str_mv |
AT lopezperezic effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT collantesfernandeze effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT rojomontejos effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT navarrolozanov effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT riscocastillov effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT perezperezvalentin effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT pereirabuenojm effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel AT ortegamoraluism effectsofneosporacaninuminfectionatmidgestationonplacentainapregnantmousemodel |
| _version_ |
1777663915220533248 |