Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model
While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans.
Main Authors: | , , |
---|---|
Format: | article biblioteca |
Language: | eng |
Subjects: | covid-19, pandémie, coronavirus 2 du syndrome respiratoire aigu sévère, provenance, transmission des maladies, modélisation, http://aims.fao.org/aos/agrovoc/c_4ad07701, http://aims.fao.org/aos/agrovoc/c_f17550ed, http://aims.fao.org/aos/agrovoc/c_365a18ab, http://aims.fao.org/aos/agrovoc/c_16022, http://aims.fao.org/aos/agrovoc/c_2329, http://aims.fao.org/aos/agrovoc/c_230ab86c, |
Online Access: | http://agritrop.cirad.fr/605907/ http://agritrop.cirad.fr/605907/1/ID605907.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-cirad-fr-605907 |
---|---|
record_format |
koha |
spelling |
dig-cirad-fr-6059072024-01-29T06:08:29Z http://agritrop.cirad.fr/605907/ http://agritrop.cirad.fr/605907/ Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model. Frutos Roger, Gavotte Laurent, Devaux Christian A.. 2021. Infection, Genetics and Evolution, 95:104812, 9 p.https://doi.org/10.1016/j.meegid.2021.104812 <https://doi.org/10.1016/j.meegid.2021.104812> Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model Frutos, Roger Gavotte, Laurent Devaux, Christian A. eng 2021 Infection, Genetics and Evolution covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/605907/1/ID605907.pdf text Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1016/j.meegid.2021.104812 10.1016/j.meegid.2021.104812 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2021.104812 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.meegid.2021.104812 |
institution |
CIRAD FR |
collection |
DSpace |
country |
Francia |
countrycode |
FR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-cirad-fr |
tag |
biblioteca |
region |
Europa del Oeste |
libraryname |
Biblioteca del CIRAD Francia |
language |
eng |
topic |
covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c |
spellingShingle |
covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c Frutos, Roger Gavotte, Laurent Devaux, Christian A. Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
description |
While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans. |
format |
article |
topic_facet |
covid-19 pandémie coronavirus 2 du syndrome respiratoire aigu sévère provenance transmission des maladies modélisation http://aims.fao.org/aos/agrovoc/c_4ad07701 http://aims.fao.org/aos/agrovoc/c_f17550ed http://aims.fao.org/aos/agrovoc/c_365a18ab http://aims.fao.org/aos/agrovoc/c_16022 http://aims.fao.org/aos/agrovoc/c_2329 http://aims.fao.org/aos/agrovoc/c_230ab86c |
author |
Frutos, Roger Gavotte, Laurent Devaux, Christian A. |
author_facet |
Frutos, Roger Gavotte, Laurent Devaux, Christian A. |
author_sort |
Frutos, Roger |
title |
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
title_short |
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
title_full |
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
title_fullStr |
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
title_full_unstemmed |
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
title_sort |
understanding the origin of covid-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model |
url |
http://agritrop.cirad.fr/605907/ http://agritrop.cirad.fr/605907/1/ID605907.pdf |
work_keys_str_mv |
AT frutosroger understandingtheoriginofcovid19requirestochangetheparadigmonzoonoticemergencefromthespillovertothecirculationmodel AT gavottelaurent understandingtheoriginofcovid19requirestochangetheparadigmonzoonoticemergencefromthespillovertothecirculationmodel AT devauxchristiana understandingtheoriginofcovid19requirestochangetheparadigmonzoonoticemergencefromthespillovertothecirculationmodel |
_version_ |
1792500607532138496 |