Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile
Leucocytes are typically considered as a whole in studies examining telomere dynamics in mammals. Such an approach may be precarious, as leucocytes represent the only nucleated blood cells in mammals, their composition varies temporally, and telomere length differs between leucocyte types. To highlight this limitation, we examined here whether seasonal variation in leucocyte composition was related to variation in telomere length in free‐ranging mandrills (Mandrilllus sphinx). We found that the leucocyte profile of mandrills varied seasonally, with lower lymphocyte proportion being observed during the long dry season presumably because of the combined effects of high nematode infection and stress at that time of the year. Interestingly, this low lymphocyte proportion during the long dry season was associated with shorter telomeres. Accordingly, based on longitudinal data, we found that seasonal changes in lymphocyte proportion were reflected by corresponding seasonal variation in telomere length. Overall, these results suggest that variation in lymphocyte proportion in blood can significantly affect telomere measurements in mammals. However, lymphocyte proportion did not entirely explain variation in telomere length. For instance, a lower lymphocyte proportion with age could not fully explain shorter telomeres in older individuals. Overall, our results show that telomere length and leucocyte profile are strongly although imperfectly intertwined, which may obscure the relationship between telomere dynamics and ageing processes in mammals.
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Subjects: | L50 - Physiologie et biochimie animales, L73 - Maladies des animaux, leucocyte, télomères, saisonnalité, http://aims.fao.org/aos/agrovoc/c_4298, http://aims.fao.org/aos/agrovoc/c_abdfcd4c, http://aims.fao.org/aos/agrovoc/c_34117, http://aims.fao.org/aos/agrovoc/c_3161, |
Online Access: | http://agritrop.cirad.fr/593504/ http://agritrop.cirad.fr/593504/1/593504.pdf |
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dig-cirad-fr-5935042024-01-29T02:17:15Z http://agritrop.cirad.fr/593504/ http://agritrop.cirad.fr/593504/ Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile. Beaulieu Michaël, Benoit Laure, Abaga Steven, Kappeler Peter M., Charpentier Marie J.E.. 2017. Molecular Ecology, 26 (20) : 5603-5613.https://doi.org/10.1111/mec.14329 <https://doi.org/10.1111/mec.14329> Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile Beaulieu, Michaël Benoit, Laure Abaga, Steven Kappeler, Peter M. Charpentier, Marie J.E. eng 2017 Molecular Ecology L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 Gabon http://aims.fao.org/aos/agrovoc/c_3161 Leucocytes are typically considered as a whole in studies examining telomere dynamics in mammals. Such an approach may be precarious, as leucocytes represent the only nucleated blood cells in mammals, their composition varies temporally, and telomere length differs between leucocyte types. To highlight this limitation, we examined here whether seasonal variation in leucocyte composition was related to variation in telomere length in free‐ranging mandrills (Mandrilllus sphinx). We found that the leucocyte profile of mandrills varied seasonally, with lower lymphocyte proportion being observed during the long dry season presumably because of the combined effects of high nematode infection and stress at that time of the year. Interestingly, this low lymphocyte proportion during the long dry season was associated with shorter telomeres. Accordingly, based on longitudinal data, we found that seasonal changes in lymphocyte proportion were reflected by corresponding seasonal variation in telomere length. Overall, these results suggest that variation in lymphocyte proportion in blood can significantly affect telomere measurements in mammals. However, lymphocyte proportion did not entirely explain variation in telomere length. For instance, a lower lymphocyte proportion with age could not fully explain shorter telomeres in older individuals. Overall, our results show that telomere length and leucocyte profile are strongly although imperfectly intertwined, which may obscure the relationship between telomere dynamics and ageing processes in mammals. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/593504/1/593504.pdf text Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1111/mec.14329 10.1111/mec.14329 info:eu-repo/semantics/altIdentifier/doi/10.1111/mec.14329 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1111/mec.14329 |
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L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 http://aims.fao.org/aos/agrovoc/c_3161 L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 http://aims.fao.org/aos/agrovoc/c_3161 |
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L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 http://aims.fao.org/aos/agrovoc/c_3161 L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 http://aims.fao.org/aos/agrovoc/c_3161 Beaulieu, Michaël Benoit, Laure Abaga, Steven Kappeler, Peter M. Charpentier, Marie J.E. Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
description |
Leucocytes are typically considered as a whole in studies examining telomere dynamics in mammals. Such an approach may be precarious, as leucocytes represent the only nucleated blood cells in mammals, their composition varies temporally, and telomere length differs between leucocyte types. To highlight this limitation, we examined here whether seasonal variation in leucocyte composition was related to variation in telomere length in free‐ranging mandrills (Mandrilllus sphinx). We found that the leucocyte profile of mandrills varied seasonally, with lower lymphocyte proportion being observed during the long dry season presumably because of the combined effects of high nematode infection and stress at that time of the year. Interestingly, this low lymphocyte proportion during the long dry season was associated with shorter telomeres. Accordingly, based on longitudinal data, we found that seasonal changes in lymphocyte proportion were reflected by corresponding seasonal variation in telomere length. Overall, these results suggest that variation in lymphocyte proportion in blood can significantly affect telomere measurements in mammals. However, lymphocyte proportion did not entirely explain variation in telomere length. For instance, a lower lymphocyte proportion with age could not fully explain shorter telomeres in older individuals. Overall, our results show that telomere length and leucocyte profile are strongly although imperfectly intertwined, which may obscure the relationship between telomere dynamics and ageing processes in mammals. |
format |
article |
topic_facet |
L50 - Physiologie et biochimie animales L73 - Maladies des animaux leucocyte télomères saisonnalité http://aims.fao.org/aos/agrovoc/c_4298 http://aims.fao.org/aos/agrovoc/c_abdfcd4c http://aims.fao.org/aos/agrovoc/c_34117 http://aims.fao.org/aos/agrovoc/c_3161 |
author |
Beaulieu, Michaël Benoit, Laure Abaga, Steven Kappeler, Peter M. Charpentier, Marie J.E. |
author_facet |
Beaulieu, Michaël Benoit, Laure Abaga, Steven Kappeler, Peter M. Charpentier, Marie J.E. |
author_sort |
Beaulieu, Michaël |
title |
Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
title_short |
Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
title_full |
Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
title_fullStr |
Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
title_full_unstemmed |
Mind the cell: Seasonal variation in telomere length mirrors changes in leucocyte profile |
title_sort |
mind the cell: seasonal variation in telomere length mirrors changes in leucocyte profile |
url |
http://agritrop.cirad.fr/593504/ http://agritrop.cirad.fr/593504/1/593504.pdf |
work_keys_str_mv |
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1792499818447241216 |