Virus population bottlenecks during within-host progression and host-to-host transmission
Despite rapidly growing to immense sizes, virus populations suffer repeated severe bottlenecks, both within hosts and when transmitted from host to host. The potential effect of bottlenecks has been theoretically and experimentally documented, but formal estimations of their actual sizes in natural situations are scarce. Bottlenecks during colonization of organs and during transmission are influenced by those occurring at the cellular level. The study of the multiplicity of cellular infection (MOI) thus appears central, and this trait may be differentially regulated by different virus species. The values of MOI and their putative regulation deserve important future efforts, in order to disentangle the complex interactions between the control of gene copy numbers and the populations dynamics/genetics of viruses.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | article biblioteca |
| Language: | eng |
| Subjects: | H20 - Maladies des plantes, L73 - Maladies des animaux, |
| Online Access: | http://agritrop.cirad.fr/590573/ http://agritrop.cirad.fr/590573/1/1-s2.0-S187962571200123X-main.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-cirad-fr-590573 |
|---|---|
| record_format |
koha |
| spelling |
dig-cirad-fr-5905732021-11-09T09:58:16Z http://agritrop.cirad.fr/590573/ http://agritrop.cirad.fr/590573/ Virus population bottlenecks during within-host progression and host-to-host transmission. Gutiérrez Serafin, Michalakis Yannis, Blanc Stéphane. 2012. Current Opinion in Virology, 2 (5) : 546-555.https://doi.org/10.1016/j.coviro.2012.08.001 <https://doi.org/10.1016/j.coviro.2012.08.001> Researchers Virus population bottlenecks during within-host progression and host-to-host transmission Gutiérrez, Serafin Michalakis, Yannis Blanc, Stéphane eng 2012 Current Opinion in Virology H20 - Maladies des plantes L73 - Maladies des animaux Despite rapidly growing to immense sizes, virus populations suffer repeated severe bottlenecks, both within hosts and when transmitted from host to host. The potential effect of bottlenecks has been theoretically and experimentally documented, but formal estimations of their actual sizes in natural situations are scarce. Bottlenecks during colonization of organs and during transmission are influenced by those occurring at the cellular level. The study of the multiplicity of cellular infection (MOI) thus appears central, and this trait may be differentially regulated by different virus species. The values of MOI and their putative regulation deserve important future efforts, in order to disentangle the complex interactions between the control of gene copy numbers and the populations dynamics/genetics of viruses. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/590573/1/1-s2.0-S187962571200123X-main.pdf text cc_by_nc_nd info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/ https://doi.org/10.1016/j.coviro.2012.08.001 10.1016/j.coviro.2012.08.001 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coviro.2012.08.001 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1016/j.coviro.2012.08.001 |
| institution |
CIRAD FR |
| collection |
DSpace |
| country |
Francia |
| countrycode |
FR |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-cirad-fr |
| tag |
biblioteca |
| region |
Europa del Oeste |
| libraryname |
Biblioteca del CIRAD Francia |
| language |
eng |
| topic |
H20 - Maladies des plantes L73 - Maladies des animaux H20 - Maladies des plantes L73 - Maladies des animaux |
| spellingShingle |
H20 - Maladies des plantes L73 - Maladies des animaux H20 - Maladies des plantes L73 - Maladies des animaux Gutiérrez, Serafin Michalakis, Yannis Blanc, Stéphane Virus population bottlenecks during within-host progression and host-to-host transmission |
| description |
Despite rapidly growing to immense sizes, virus populations suffer repeated severe bottlenecks, both within hosts and when transmitted from host to host. The potential effect of bottlenecks has been theoretically and experimentally documented, but formal estimations of their actual sizes in natural situations are scarce. Bottlenecks during colonization of organs and during transmission are influenced by those occurring at the cellular level. The study of the multiplicity of cellular infection (MOI) thus appears central, and this trait may be differentially regulated by different virus species. The values of MOI and their putative regulation deserve important future efforts, in order to disentangle the complex interactions between the control of gene copy numbers and the populations dynamics/genetics of viruses. |
| format |
article |
| topic_facet |
H20 - Maladies des plantes L73 - Maladies des animaux |
| author |
Gutiérrez, Serafin Michalakis, Yannis Blanc, Stéphane |
| author_facet |
Gutiérrez, Serafin Michalakis, Yannis Blanc, Stéphane |
| author_sort |
Gutiérrez, Serafin |
| title |
Virus population bottlenecks during within-host progression and host-to-host transmission |
| title_short |
Virus population bottlenecks during within-host progression and host-to-host transmission |
| title_full |
Virus population bottlenecks during within-host progression and host-to-host transmission |
| title_fullStr |
Virus population bottlenecks during within-host progression and host-to-host transmission |
| title_full_unstemmed |
Virus population bottlenecks during within-host progression and host-to-host transmission |
| title_sort |
virus population bottlenecks during within-host progression and host-to-host transmission |
| url |
http://agritrop.cirad.fr/590573/ http://agritrop.cirad.fr/590573/1/1-s2.0-S187962571200123X-main.pdf |
| work_keys_str_mv |
AT gutierrezserafin viruspopulationbottlenecksduringwithinhostprogressionandhosttohosttransmission AT michalakisyannis viruspopulationbottlenecksduringwithinhostprogressionandhosttohosttransmission AT blancstephane viruspopulationbottlenecksduringwithinhostprogressionandhosttohosttransmission |
| _version_ |
1758026014850547712 |