RNA interference as antiviral therapy: Dream or reality?

RNA interference as antiviral therapy: Dream or reality?

Soon aft er discovery of RNA interference (RNAi), its potential as eff ective antiviral therapy was recognized. Since then RNAi has been variously exploited for antiviral purposes which could eff ectively block viral replication in vitro. For invivo use, however, delivery issue, toxicity, RNAi suppression and viral escape are still major hurdles. Here, we providean overview of the RNAi strategy and review the approaches that have been developed to surpass the obstacles and to achieve targeted gene silencing for antiviral and other therapies.

Saved in:
Bibliographic Details
Main Authors: Nizamani, Zaheer Ahmed, Holz, Carine, Keita, Djénéba, Libeau, Geneviève, Albina, Emmanuel, Servan de Almeida, Renata
Format: article biblioteca
Language:eng
Subjects:L73 - Maladies des animaux,
Online Access:http://agritrop.cirad.fr/572735/
http://agritrop.cirad.fr/572735/1/document_572735.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-cirad-fr-572735
record_format koha
spelling dig-cirad-fr-5727352022-03-30T15:05:16Z http://agritrop.cirad.fr/572735/ http://agritrop.cirad.fr/572735/ RNA interference as antiviral therapy: Dream or reality? Nizamani Zaheer Ahmed, Holz Carine, Keita Djénéba, Libeau Geneviève, Albina Emmanuel, Servan de Almeida Renata. 2013. Virus Reviews and Research, 18 (1-2), 16 p.http://157.86.113.86/index.php/vrrjournal/search/authors/view?firstName=Carine&middleName=&lastName=Holz&affiliation=&country= <http://157.86.113.86/index.php/vrrjournal/search/authors/view?firstName=Carine&middleName=&lastName=Holz&affiliation=&country=> Researchers RNA interference as antiviral therapy: Dream or reality? Nizamani, Zaheer Ahmed Holz, Carine Keita, Djénéba Libeau, Geneviève Albina, Emmanuel Servan de Almeida, Renata eng 2013 Virus Reviews and Research L73 - Maladies des animaux Soon aft er discovery of RNA interference (RNAi), its potential as eff ective antiviral therapy was recognized. Since then RNAi has been variously exploited for antiviral purposes which could eff ectively block viral replication in vitro. For invivo use, however, delivery issue, toxicity, RNAi suppression and viral escape are still major hurdles. Here, we providean overview of the RNAi strategy and review the approaches that have been developed to surpass the obstacles and to achieve targeted gene silencing for antiviral and other therapies. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/572735/1/document_572735.pdf application/pdf Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html http://157.86.113.86/index.php/vrrjournal/search/authors/view?firstName=Carine&middleName=&lastName=Holz&affiliation=&country= info:eu-repo/semantics/altIdentifier/purl/http://157.86.113.86/index.php/vrrjournal/search/authors/view?firstName=Carine&middleName=&lastName=Holz&affiliation=&country=
institution CIRAD FR
collection DSpace
country Francia
countrycode FR
component Bibliográfico
access En linea
databasecode dig-cirad-fr
tag biblioteca
region Europa del Oeste
libraryname Biblioteca del CIRAD Francia
language eng
topic L73 - Maladies des animaux
L73 - Maladies des animaux
spellingShingle L73 - Maladies des animaux
L73 - Maladies des animaux
Nizamani, Zaheer Ahmed
Holz, Carine
Keita, Djénéba
Libeau, Geneviève
Albina, Emmanuel
Servan de Almeida, Renata
RNA interference as antiviral therapy: Dream or reality?
description Soon aft er discovery of RNA interference (RNAi), its potential as eff ective antiviral therapy was recognized. Since then RNAi has been variously exploited for antiviral purposes which could eff ectively block viral replication in vitro. For invivo use, however, delivery issue, toxicity, RNAi suppression and viral escape are still major hurdles. Here, we providean overview of the RNAi strategy and review the approaches that have been developed to surpass the obstacles and to achieve targeted gene silencing for antiviral and other therapies.
format article
topic_facet L73 - Maladies des animaux
author Nizamani, Zaheer Ahmed
Holz, Carine
Keita, Djénéba
Libeau, Geneviève
Albina, Emmanuel
Servan de Almeida, Renata
author_facet Nizamani, Zaheer Ahmed
Holz, Carine
Keita, Djénéba
Libeau, Geneviève
Albina, Emmanuel
Servan de Almeida, Renata
author_sort Nizamani, Zaheer Ahmed
title RNA interference as antiviral therapy: Dream or reality?
title_short RNA interference as antiviral therapy: Dream or reality?
title_full RNA interference as antiviral therapy: Dream or reality?
title_fullStr RNA interference as antiviral therapy: Dream or reality?
title_full_unstemmed RNA interference as antiviral therapy: Dream or reality?
title_sort rna interference as antiviral therapy: dream or reality?
url http://agritrop.cirad.fr/572735/
http://agritrop.cirad.fr/572735/1/document_572735.pdf
work_keys_str_mv AT nizamanizaheerahmed rnainterferenceasantiviraltherapydreamorreality
AT holzcarine rnainterferenceasantiviraltherapydreamorreality
AT keitadjeneba rnainterferenceasantiviraltherapydreamorreality
AT libeaugenevieve rnainterferenceasantiviraltherapydreamorreality
AT albinaemmanuel rnainterferenceasantiviraltherapydreamorreality
AT servandealmeidarenata rnainterferenceasantiviraltherapydreamorreality
_version_ 1758024110533771264

Similar Items