Congopain from Trypanosoma congolense : drug target and vaccine candidate
Trypanosomes are the etiological agents of human sleeping sickness and livestock trypanosomosis (nagana), which are major diseases in Africa. Their cysteine proteases (CPs), which are members of the papain family, are expressed during the infective stages of the parasites' life cycle. They are suspected to act as pathogenic factors in the mammalian host, where they also trigger prominent immune responses. Trypanosoma congolense, a major pathogenic species in livestock, possesses at least two families of closely related CPs, named CPi and CP2. Congopain, a CP2-type of enzyme, shares structural and functional resemblances with cruzipain from T. cruzi and with mammalian cathepsin L. Like CPs from other Trypanosomatids, congopain might be an attractive target for trypanocidal drugs. Here we summarise the current knowledge in the two main areas of research on congopain: first, the biochemical properties of congopain were characterised and its substrate specificity was determined, as a first step towards drug design; second, the possibility was being explored that inhibition of congopain by host-specific antibodies may mitigate the pathology associated with trypanosome infection.
Main Authors: | , , , , , , |
---|---|
Format: | article biblioteca |
Language: | eng |
Subjects: | L73 - Maladies des animaux, L72 - Organismes nuisibles des animaux, |
Online Access: | http://agritrop.cirad.fr/542066/ http://agritrop.cirad.fr/542066/1/document_542066.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-cirad-fr-542066 |
---|---|
record_format |
koha |
spelling |
dig-cirad-fr-5420662022-08-16T16:00:36Z http://agritrop.cirad.fr/542066/ http://agritrop.cirad.fr/542066/ Congopain from Trypanosoma congolense : drug target and vaccine candidate. Lalmanach Gilles, Boulangé Alain, Serveau Carole, Lecaille Fabien, Scharfstein Julio, Gauthier Francis, Authié Edith. 2002. Biological Chemistry, 383 : 739-749.https://doi.org/10.1515/BC.2002.077 <https://doi.org/10.1515/BC.2002.077> Researchers Congopain from Trypanosoma congolense : drug target and vaccine candidate Lalmanach, Gilles Boulangé, Alain Serveau, Carole Lecaille, Fabien Scharfstein, Julio Gauthier, Francis Authié, Edith eng 2002 Biological Chemistry L73 - Maladies des animaux L72 - Organismes nuisibles des animaux Trypanosomes are the etiological agents of human sleeping sickness and livestock trypanosomosis (nagana), which are major diseases in Africa. Their cysteine proteases (CPs), which are members of the papain family, are expressed during the infective stages of the parasites' life cycle. They are suspected to act as pathogenic factors in the mammalian host, where they also trigger prominent immune responses. Trypanosoma congolense, a major pathogenic species in livestock, possesses at least two families of closely related CPs, named CPi and CP2. Congopain, a CP2-type of enzyme, shares structural and functional resemblances with cruzipain from T. cruzi and with mammalian cathepsin L. Like CPs from other Trypanosomatids, congopain might be an attractive target for trypanocidal drugs. Here we summarise the current knowledge in the two main areas of research on congopain: first, the biochemical properties of congopain were characterised and its substrate specificity was determined, as a first step towards drug design; second, the possibility was being explored that inhibition of congopain by host-specific antibodies may mitigate the pathology associated with trypanosome infection. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/542066/1/document_542066.pdf application/pdf Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1515/BC.2002.077 10.1515/BC.2002.077 http://catalogue-bibliotheques.cirad.fr/cgi-bin/koha/opac-detail.pl?biblionumber=161585 info:eu-repo/semantics/altIdentifier/doi/10.1515/BC.2002.077 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1515/BC.2002.077 |
institution |
CIRAD FR |
collection |
DSpace |
country |
Francia |
countrycode |
FR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-cirad-fr |
tag |
biblioteca |
region |
Europa del Oeste |
libraryname |
Biblioteca del CIRAD Francia |
language |
eng |
topic |
L73 - Maladies des animaux L72 - Organismes nuisibles des animaux L73 - Maladies des animaux L72 - Organismes nuisibles des animaux |
spellingShingle |
L73 - Maladies des animaux L72 - Organismes nuisibles des animaux L73 - Maladies des animaux L72 - Organismes nuisibles des animaux Lalmanach, Gilles Boulangé, Alain Serveau, Carole Lecaille, Fabien Scharfstein, Julio Gauthier, Francis Authié, Edith Congopain from Trypanosoma congolense : drug target and vaccine candidate |
description |
Trypanosomes are the etiological agents of human sleeping sickness and livestock trypanosomosis (nagana), which are major diseases in Africa. Their cysteine proteases (CPs), which are members of the papain family, are expressed during the infective stages of the parasites' life cycle. They are suspected to act as pathogenic factors in the mammalian host, where they also trigger prominent immune responses. Trypanosoma congolense, a major pathogenic species in livestock, possesses at least two families of closely related CPs, named CPi and CP2. Congopain, a CP2-type of enzyme, shares structural and functional resemblances with cruzipain from T. cruzi and with mammalian cathepsin L. Like CPs from other Trypanosomatids, congopain might be an attractive target for trypanocidal drugs. Here we summarise the current knowledge in the two main areas of research on congopain: first, the biochemical properties of congopain were characterised and its substrate specificity was determined, as a first step towards drug design; second, the possibility was being explored that inhibition of congopain by host-specific antibodies may mitigate the pathology associated with trypanosome infection. |
format |
article |
topic_facet |
L73 - Maladies des animaux L72 - Organismes nuisibles des animaux |
author |
Lalmanach, Gilles Boulangé, Alain Serveau, Carole Lecaille, Fabien Scharfstein, Julio Gauthier, Francis Authié, Edith |
author_facet |
Lalmanach, Gilles Boulangé, Alain Serveau, Carole Lecaille, Fabien Scharfstein, Julio Gauthier, Francis Authié, Edith |
author_sort |
Lalmanach, Gilles |
title |
Congopain from Trypanosoma congolense : drug target and vaccine candidate |
title_short |
Congopain from Trypanosoma congolense : drug target and vaccine candidate |
title_full |
Congopain from Trypanosoma congolense : drug target and vaccine candidate |
title_fullStr |
Congopain from Trypanosoma congolense : drug target and vaccine candidate |
title_full_unstemmed |
Congopain from Trypanosoma congolense : drug target and vaccine candidate |
title_sort |
congopain from trypanosoma congolense : drug target and vaccine candidate |
url |
http://agritrop.cirad.fr/542066/ http://agritrop.cirad.fr/542066/1/document_542066.pdf |
work_keys_str_mv |
AT lalmanachgilles congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT boulangealain congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT serveaucarole congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT lecaillefabien congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT scharfsteinjulio congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT gauthierfrancis congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate AT authieedith congopainfromtrypanosomacongolensedrugtargetandvaccinecandidate |
_version_ |
1758021453731594240 |