Analysis of psychoactive substances in water by information dependent acquisition on a hybrid quadrupole time-of-flight mass spectrometer
Emerging drugs of abuse, belonging to many different chemical classes, are attracting users with promises of “legal” highs and easy access via internet. Prevalence of their consumption and abuse through wastewater-based epidemiology can only be realized if a suitable analytical screening procedure exists to detect and quantify them in water. Solid-phase extraction and ultra-high performance liquid chromatography quadrupole time-of-flight-mass spectrometry (UHPLC–QqTOF–MS/MS) was applied for rapid suspect screening as well as for the quantitative determination of 42 illicit drugs and metabolites in water. Using this platform, we were able to identify amphetamines, tryptamines, piperazines, pyrrolidinophenones, arylcyclohexylamines, cocainics, opioids and cannabinoids. Additionally, paracetamol, carbamazepine, ibersartan, valsartan, sulfamethoxazole, terbumeton, diuron, etc. (including degradation products as 3-hydroxy carbamazepine or deethylterbuthylazine) were detected. This method encompasses easy sample preparation and rapid identification of psychoactive drugs against a database that cover more than 2000 compounds that ionized in positive mode, and possibility to identify metabolites and degradation products as well as unknown compounds. The method for river water, influent and effluents samples was fully validated for the target psychoactive substances including assessment of matrix effects (-88–67.8%), recovery (42–115%), precision (<19%) and limits of quantification (1–100 ng L). Method efficiency was thoroughly investigated for a wide range of waste and surface waters. Robust and repeatable functioning of this platform in the screening, identification and quantification of traditional and new psychoactive drugs biomarkers and other water contaminants is demonstrated.
Main Authors: | Andrés-Costa, María Jesús, Andreu Pérez, V., Picó, Yolanda |
---|---|
Other Authors: | Ministerio de Economía y Competitividad (España) |
Format: | artículo biblioteca |
Published: |
Elsevier
2016-08-26
|
Subjects: | Quantification, Screening, Water, High resolution mass spectrometry, Psychoactive drugs, |
Online Access: | http://hdl.handle.net/10261/141059 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
A fully automated approach for the analysis of 37 psychoactive substances in raw wastewater based on on-line solid phase extraction-liquid chromatography-tandem mass spectrometry
by: López-García, Ester, et al.
Published: (2018-11-16) -
Determination of lipophilic marine toxins in mussels. Quantification and confirmation criteria using high resolution mass spectrometry
by: Domènech, Albert, et al.
Published: (2014) -
Suspect screening of natural toxins in surface and drinking water by high performance liquid chromatography and high-resolution mass spectrometry
by: Picardo, Massimo, et al.
Published: (2020-12) -
Suspect, non-target and target screening of emerging pollutants using data independent acquisition: Assessment of a Mediterranean River basin
by: Ccanccapa, Alexander, et al.
Published: (2019-06-21) -
A step forward in the detection of byproducts of anthropogenic organic micropollutants in chlorinated water
by: Postigo, Cristina, et al.
Published: (2021-12-01)