Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation
[Introduction]: Preterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones are present in BM, it is possible that their levels may equilibrate deficiencies improving infant growth. We aimed to assess 1) the BM levels of ghrelin, resistin, leptin, insulin, peptide YY, and the gastrointestinal peptide in women with preterm and term labor; 2) the relationship between BM hormones and neonatal growth; and 3) the influence of maternal body composition and diet on these BM hormones.
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2023
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dig-cial-es-10261-3340632023-08-29T09:38:03Z Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation Ramiro-Cortijo, David Singh, Pratibha Herranz Carrillo, Gloria Gila-Diaz, Andrea Martín-Cabrejas, María A. Martin, Camilia R. Arribas, Silvia M. Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Alter Universidad Autónoma de Madrid [Introduction]: Preterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones are present in BM, it is possible that their levels may equilibrate deficiencies improving infant growth. We aimed to assess 1) the BM levels of ghrelin, resistin, leptin, insulin, peptide YY, and the gastrointestinal peptide in women with preterm and term labor; 2) the relationship between BM hormones and neonatal growth; and 3) the influence of maternal body composition and diet on these BM hormones. [Methods]: BM from 48 women (30 term and 18 preterm labor) was collected at days 7, 14, and 28 of lactation. Maternal body composition was evaluated by bioimpedance, and neonate anthropometric parameters were collected from medical records. The maternal dietary pattern was assessed by a 72-h dietary recall at days 7 and 28 of lactation. BM hormones were analyzed by the U-Plex Ultra-sensitive method. Data were analyzed using linear regression models. BM from women with preterm labor had lower ghrelin levels, with the other hormones being significantly higher compared to women with term delivery. [Results]: In premature infants, growth was positively associated with BM ghrelin, while, in term infants, it was positively associated with insulin and negatively with peptide YY. In the first week of lactation, women with preterm labor had higher body fat compared to women with term labor. In this group, ghrelin levels were positively associated with maternal body fat and with fiber and protein intake. In women with term labor, no associations between anthropometric parameters and BM hormones were found, and fiber intake was negatively associated with peptide YY. [Discussion]: Preterm labor is a factor influencing the levels of BM adipokines and gut hormones, with BM ghrelin being a relevant hormone for premature infant growth. Since ghrelin is lower in BM from women with preterm labor and the levels are associated with maternal fat storage and some dietary components, our data support the importance to monitor diet and body composition in women who gave birth prematurely to improve the BM hormonal status. This research was funded by Promotion of Knowledge Transfer program (PTC-2020) from Universidad Autónoma de Madrid in collaboration with Alter Farmacia, SA, Spanish Ministry of Science, and Innovation ( ). Peer reviewed 2023-08-29T09:38:02Z 2023-08-29T09:38:02Z 2023 artículo Frontiers in Endocrinology 14: 1090499 (2023) http://hdl.handle.net/10261/334063 10.3389/fendo.2023.1090499 1664-2392 36936154 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097504-B-I00/ES/NUEVOS INGREDIENTES ANTIOXIDANTES DE SUBPRODUCTOS DE CAFE Y CACAO COMO ESTRATEGIA PARA REPROGRAMAR LA ENFERMEDAD CARDIOMETABOLICA A TRAVES DE LA LACTANCIA/ Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3389/fendo.2023.1090499 https://doi.org/10.3389/fendo.2023.1090499 Sí open application/pdf Frontiers Media |
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[Introduction]: Preterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones are present in BM, it is possible that their levels may equilibrate deficiencies improving infant growth. We aimed to assess 1) the BM levels of ghrelin, resistin, leptin, insulin, peptide YY, and the gastrointestinal peptide in women with preterm and term labor; 2) the relationship between BM hormones and neonatal growth; and 3) the influence of maternal body composition and diet on these BM hormones. |
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Ministerio de Ciencia, Innovación y Universidades (España) |
| author_facet |
Ministerio de Ciencia, Innovación y Universidades (España) Ramiro-Cortijo, David Singh, Pratibha Herranz Carrillo, Gloria Gila-Diaz, Andrea Martín-Cabrejas, María A. Martin, Camilia R. Arribas, Silvia M. |
| format |
artículo |
| author |
Ramiro-Cortijo, David Singh, Pratibha Herranz Carrillo, Gloria Gila-Diaz, Andrea Martín-Cabrejas, María A. Martin, Camilia R. Arribas, Silvia M. |
| spellingShingle |
Ramiro-Cortijo, David Singh, Pratibha Herranz Carrillo, Gloria Gila-Diaz, Andrea Martín-Cabrejas, María A. Martin, Camilia R. Arribas, Silvia M. Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| author_sort |
Ramiro-Cortijo, David |
| title |
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_short |
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_full |
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_fullStr |
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_full_unstemmed |
Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_sort |
association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| publisher |
Frontiers Media |
| publishDate |
2023 |
| url |
http://hdl.handle.net/10261/334063 |
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