Coffee silverskin extract protects against accelerated aging caused by oxidative agents
Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material
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Multidisciplinary Digital Publishing Institute
2016-06-01
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Online Access: | http://hdl.handle.net/10261/142070 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 |
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dig-cial-es-10261-1420702021-12-27T16:17:52Z Coffee silverskin extract protects against accelerated aging caused by oxidative agents Iriondo-DeHond, Amaia Martorell, Patricia Genovés, Salvador Ramón, Daniel Stamatakis, Konstantinos Fresno, Manuel Molina, Antonio Castillo, M. Dolores del Consejo Superior de Investigaciones Científicas (España) Ministerio de Economía y Competitividad (España) Asociación Española Contra el Cáncer Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material The authors are grateful for the financial support from the SUSCOFFEE Project (AGL2014-57239-R) and the NATURAGE Project (AGL2010-17779). This work was partially funded by a Santander Small and Medium Enterprises Work Placement Grant in Beacon Biomedicine. Amaia Iriondo is a fellow of the FPI predoctoral program of the Ministry of Economy and Competitiveness (BES-2015-072191). Konstantinos Stamatakis is a recipient of an Asociación Española Contra el Cancer fellowship. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). 2017-01-04T08:46:35Z 2017-01-04T08:46:35Z 2016-06-01 2017-01-04T08:46:35Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.3390/molecules21060721 Molecules 21(6): 721 (2016) 1420-3049 http://hdl.handle.net/10261/142070 10.3390/molecules21060721 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 27258247 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-57239-R http://dx.doi.org/10.3390/molecules21060721 open Multidisciplinary Digital Publishing Institute |
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Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material |
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Consejo Superior de Investigaciones Científicas (España) |
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Consejo Superior de Investigaciones Científicas (España) Iriondo-DeHond, Amaia Martorell, Patricia Genovés, Salvador Ramón, Daniel Stamatakis, Konstantinos Fresno, Manuel Molina, Antonio Castillo, M. Dolores del |
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Iriondo-DeHond, Amaia Martorell, Patricia Genovés, Salvador Ramón, Daniel Stamatakis, Konstantinos Fresno, Manuel Molina, Antonio Castillo, M. Dolores del |
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Iriondo-DeHond, Amaia Martorell, Patricia Genovés, Salvador Ramón, Daniel Stamatakis, Konstantinos Fresno, Manuel Molina, Antonio Castillo, M. Dolores del Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
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Iriondo-DeHond, Amaia |
title |
Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
title_short |
Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
title_full |
Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
title_fullStr |
Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
title_full_unstemmed |
Coffee silverskin extract protects against accelerated aging caused by oxidative agents |
title_sort |
coffee silverskin extract protects against accelerated aging caused by oxidative agents |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2016-06-01 |
url |
http://hdl.handle.net/10261/142070 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 |
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