Molecular Neuropharmacology [electronic resource] : Strategies and Methods /
The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available. State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases.
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Format: | Texto biblioteca |
Language: | eng |
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Totowa, NJ : Humana Press : Imprint: Humana Press,
2004
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Subjects: | Medicine., Molecular biology., Neurosciences., Neurology., Psychopharmacology., Medicine & Public Health., Molecular Medicine., |
Online Access: | http://dx.doi.org/10.1007/978-1-59259-672-0 |
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Medicine. Molecular biology. Neurosciences. Neurology. Psychopharmacology. Medicine & Public Health. Psychopharmacology. Neurology. Molecular Medicine. Neurosciences. Medicine. Molecular biology. Neurosciences. Neurology. Psychopharmacology. Medicine & Public Health. Psychopharmacology. Neurology. Molecular Medicine. Neurosciences. |
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Medicine. Molecular biology. Neurosciences. Neurology. Psychopharmacology. Medicine & Public Health. Psychopharmacology. Neurology. Molecular Medicine. Neurosciences. Medicine. Molecular biology. Neurosciences. Neurology. Psychopharmacology. Medicine & Public Health. Psychopharmacology. Neurology. Molecular Medicine. Neurosciences. Schousboe, Arne. editor. Bräuner-Osborne, Hans. editor. SpringerLink (Online service) Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available. State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases. |
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Medicine. Molecular biology. Neurosciences. Neurology. Psychopharmacology. Medicine & Public Health. Psychopharmacology. Neurology. Molecular Medicine. Neurosciences. |
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Schousboe, Arne. editor. Bräuner-Osborne, Hans. editor. SpringerLink (Online service) |
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Schousboe, Arne. editor. Bräuner-Osborne, Hans. editor. SpringerLink (Online service) |
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Schousboe, Arne. editor. |
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Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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Molecular Neuropharmacology [electronic resource] : Strategies and Methods / |
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molecular neuropharmacology [electronic resource] : strategies and methods / |
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Totowa, NJ : Humana Press : Imprint: Humana Press, |
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2004 |
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http://dx.doi.org/10.1007/978-1-59259-672-0 |
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AT schousboearneeditor molecularneuropharmacologyelectronicresourcestrategiesandmethods AT braunerosbornehanseditor molecularneuropharmacologyelectronicresourcestrategiesandmethods AT springerlinkonlineservice molecularneuropharmacologyelectronicresourcestrategiesandmethods |
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KOHA-OAI-TEST:2070342018-07-30T23:37:25ZMolecular Neuropharmacology [electronic resource] : Strategies and Methods / Schousboe, Arne. editor. Bräuner-Osborne, Hans. editor. SpringerLink (Online service) textTotowa, NJ : Humana Press : Imprint: Humana Press,2004.engThe ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available. State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases.I. Molecular Pharmacology of Glutamate Receptors -- 1 Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors -- 2 Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands -- 3 Molecular Pharmacology of the Metabotropic Glutamate Receptors -- II. Molecular Pharmacology of GABA Receptors -- 4 Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity -- 5 In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice -- 6 Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling -- 7 The GABAB Receptor: From Cloning to Knockout Mice -- III. Molecular Pharmacology of Transmitter Transporters -- 8 Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters -- 9 Allosteric Modulation of Glutamate Transporters -- 10 Characterization of the Substrate-Binding Site in GABA Transporters -- 11 Insights From Endogenous and Engineered Zn2+ Binding Sites in Monoamine Transporters -- 12 A Structural Context for Studying Neurotransmitter Transporter Function -- 13 Functional Mechanisms of G Protein-Coupled Receptors in a Structural Context.The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available. State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases.Medicine.Molecular biology.Neurosciences.Neurology.Psychopharmacology.Medicine & Public Health.Psychopharmacology.Neurology.Molecular Medicine.Neurosciences.Springer eBookshttp://dx.doi.org/10.1007/978-1-59259-672-0URN:ISBN:9781592596720 |