Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride
This study aimed to evaluate zilpaterol hydrochloride (ZH, generic) supplementation on fattening hair sheep, using hematological and biochemical variables as health status indicators. A total of 32 hair lambs (Dorper x Pelibuey) were grouped by initial weight and randomly assigned into four treatments: T1= basal diet (control group), T2= basal diet supplemented with ZH at 0.10 mg·kg-1 of LW d-1 (Grofactor®, Virbac México, Guadalajara, Mexico), T3= basal diet supplemented with ZH at 0.20 mg·kg-1 of LW d-1, and T4= basal diet supplemented with ZH at 0.30 mg·kg-1 of LW d-1. Blood samples were collected on days 1, 15, and 30 of the study. The hematological profile was determined in fresh blood samples; metabolites, electrolytes, and hormones were determined in serum samples. The study followed a randomized complete block experimental design, using an orthogonal polynomial analysis to determine the trend of the responses at the different concentrations of ZH. Cholesterol and urea levels were higher (P<0.05) in T3 than in T2. Furthermore, the mean corpuscular hemoglobin concentration was higher (P<0.05) in T1 than in T3; the red blood cell distribution width was higher (P<0.05) in T2 and T3 than in T4. The Na levels and the number of platelets showed a linear trend (P <0.05) to decrease and increase, respectively, as ZH levels increased. A quadratic trend was observed (P<0.05) in mean corpuscular hemoglobin concentration and red blood cell distribution width with increasing dose of ZH (generic). The remaining variables did not show significant trends at ZH levels (generic). The values of the biochemical and hematological profiles were within the reference range, which suggests that the addition of ZH did not alter the health status of fattening lambs.
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Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias
2020
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Vicente Pérez, Arnulfo Avendaño Reyes, Leonel Macías Cruz, Ulises Aguilar Quiñones, Antonio Vicente Pérez, Ricardo Mellado, Miguel Gastélum Delgado, Miguel Ángel Correa Calderón, Abelardo López-Rincón, G. Barajas Cruz, Rubén Guerra Liera, Juan Eulogio |
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Vicente Pérez, Arnulfo Avendaño Reyes, Leonel Macías Cruz, Ulises Aguilar Quiñones, Antonio Vicente Pérez, Ricardo Mellado, Miguel Gastélum Delgado, Miguel Ángel Correa Calderón, Abelardo López-Rincón, G. Barajas Cruz, Rubén Guerra Liera, Juan Eulogio Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
author_facet |
Vicente Pérez, Arnulfo Avendaño Reyes, Leonel Macías Cruz, Ulises Aguilar Quiñones, Antonio Vicente Pérez, Ricardo Mellado, Miguel Gastélum Delgado, Miguel Ángel Correa Calderón, Abelardo López-Rincón, G. Barajas Cruz, Rubén Guerra Liera, Juan Eulogio |
author_sort |
Vicente Pérez, Arnulfo |
title |
Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
title_short |
Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
title_full |
Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
title_fullStr |
Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
title_full_unstemmed |
Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
title_sort |
evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride |
description |
This study aimed to evaluate zilpaterol hydrochloride (ZH, generic) supplementation on fattening hair sheep, using hematological and biochemical variables as health status indicators. A total of 32 hair lambs (Dorper x Pelibuey) were grouped by initial weight and randomly assigned into four treatments: T1= basal diet (control group), T2= basal diet supplemented with ZH at 0.10 mg·kg-1 of LW d-1 (Grofactor®, Virbac México, Guadalajara, Mexico), T3= basal diet supplemented with ZH at 0.20 mg·kg-1 of LW d-1, and T4= basal diet supplemented with ZH at 0.30 mg·kg-1 of LW d-1. Blood samples were collected on days 1, 15, and 30 of the study. The hematological profile was determined in fresh blood samples; metabolites, electrolytes, and hormones were determined in serum samples. The study followed a randomized complete block experimental design, using an orthogonal polynomial analysis to determine the trend of the responses at the different concentrations of ZH. Cholesterol and urea levels were higher (P<0.05) in T3 than in T2. Furthermore, the mean corpuscular hemoglobin concentration was higher (P<0.05) in T1 than in T3; the red blood cell distribution width was higher (P<0.05) in T2 and T3 than in T4. The Na levels and the number of platelets showed a linear trend (P <0.05) to decrease and increase, respectively, as ZH levels increased. A quadratic trend was observed (P<0.05) in mean corpuscular hemoglobin concentration and red blood cell distribution width with increasing dose of ZH (generic). The remaining variables did not show significant trends at ZH levels (generic). The values of the biochemical and hematological profiles were within the reference range, which suggests that the addition of ZH did not alter the health status of fattening lambs. |
publisher |
Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias |
publishDate |
2020 |
url |
https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/5192 |
work_keys_str_mv |
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rev-remexcp-article51922023-02-14T17:39:14Z Evaluation of the biochemical and hematological profiles of feedlot hair sheep after the supplementation with generic zilpaterol hydrochloride Efecto de la adición de clorhidrato de zilpaterol genérico en el perfil bioquímico y hematológico de ovinos de pelo engordados en corral Vicente Pérez, Arnulfo Avendaño Reyes, Leonel Macías Cruz, Ulises Aguilar Quiñones, Antonio Vicente Pérez, Ricardo Mellado, Miguel Gastélum Delgado, Miguel Ángel Correa Calderón, Abelardo López-Rincón, G. Barajas Cruz, Rubén Guerra Liera, Juan Eulogio Hemoglobin; Lambs; Metabolites; Electrolytes; Zilpaterol hydrochloride Hemoglobina; Corderos; Metabolitos; Electrolitos; Clorhidrato de zilpaterol This study aimed to evaluate zilpaterol hydrochloride (ZH, generic) supplementation on fattening hair sheep, using hematological and biochemical variables as health status indicators. A total of 32 hair lambs (Dorper x Pelibuey) were grouped by initial weight and randomly assigned into four treatments: T1= basal diet (control group), T2= basal diet supplemented with ZH at 0.10 mg·kg-1 of LW d-1 (Grofactor®, Virbac México, Guadalajara, Mexico), T3= basal diet supplemented with ZH at 0.20 mg·kg-1 of LW d-1, and T4= basal diet supplemented with ZH at 0.30 mg·kg-1 of LW d-1. Blood samples were collected on days 1, 15, and 30 of the study. The hematological profile was determined in fresh blood samples; metabolites, electrolytes, and hormones were determined in serum samples. The study followed a randomized complete block experimental design, using an orthogonal polynomial analysis to determine the trend of the responses at the different concentrations of ZH. Cholesterol and urea levels were higher (P<0.05) in T3 than in T2. Furthermore, the mean corpuscular hemoglobin concentration was higher (P<0.05) in T1 than in T3; the red blood cell distribution width was higher (P<0.05) in T2 and T3 than in T4. The Na levels and the number of platelets showed a linear trend (P <0.05) to decrease and increase, respectively, as ZH levels increased. A quadratic trend was observed (P<0.05) in mean corpuscular hemoglobin concentration and red blood cell distribution width with increasing dose of ZH (generic). The remaining variables did not show significant trends at ZH levels (generic). The values of the biochemical and hematological profiles were within the reference range, which suggests that the addition of ZH did not alter the health status of fattening lambs. El objetivo fue evaluar la adición de clorhidrato de zilpaterol (CZ, genérico) en la dieta de ovinos de pelo de engorda, sobre variables hematológicas y bioquímicas como indicadores del estado de salud. Treinta y dos (32) corderos de pelo cruzados (Dorper x Pelibuey) se bloquearon por peso inicial y cuatro tratamientos y se asignaron aleatoriamente dentro de cada bloque: T1= dieta basal (grupo testigo), T2= dieta basal más 0.10 mg·kg-1 de PV d-1 de CZ (Grofactor®, Virbac México, Guadalajara, México), T3= dieta basal más 0.20 mg·kg-1 de PV d-1 de CZ y T4= dieta basal más 0.30 mg·kg-1 de PV d-1 de CZ. Se tomaron muestras de sangre los días 1, 15 y 30 del estudio. El perfil hematológico se estimó en muestras de sangre fresca, mientras que metabolitos, electrolitos y hormonas en muestras de suero. El diseño experimental fue bloques completos al azar y se efectuó análisis de polinomios ortogonales para determinar la tendencia de las respuestas a los niveles de CZ. Los niveles de colesterol y urea fueron mayores (P<0.05) en T3 que en T2; asimismo, el nivel de concentración corpuscular medio de hemoglobina fue mayor (P<0.05) en T1 que en T3, mientras que el ancho de distribución de eritrocitos fue mayor (P<0.05) en T2 y T3 que en T4. Los niveles de Na y el número de plaquetas mostraron tendencia lineal (P<0.05) a disminuir y aumentar, respectivamente, conforme los niveles de CZ aumentaron. Se observó tendencia cuadrática (P<0.05) en la concentración corpuscular media de hemoglobina y ancho de distribución de eritrocitos al aumentar la dosis de CZ (genérico). Las variables restantes no mostraron tendencias significativas a los niveles de CZ (genérico). Los valores de los perfiles bioquímico y hematológico se encontraron dentro del rango de referencia, lo que sugiere que la adición de CZ no alteró el estado de salud de corderos en engorda. Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias SECRETARIA DE EDUCACIÓN PUBLICA, PROYECTOS DE INVESTIGACIÓN PARA CUERPOS ACADÉMICOS FONDO EDUCACIÓN SUPERIOR EMPRESA, A.C. 2020-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/pdf text/html https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/5192 10.22319/rmcp.v11i4.5192 Revista Mexicana de Ciencias Pecuarias; Vol. 11, Núm. 4 (2020): Octubre-Diciembre; 1208-1219 Revista Mexicana de Ciencias Pecuarias; Vol. 11, Núm. 4 (2020): Octubre-Diciembre; 1208-1219 2448-6698 2007-1124 spa eng https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/5192/4474 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/5192/4475 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/5192/5117 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/downloadSuppFile/5192/1289 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/downloadSuppFile/5192/1660 http://creativecommons.org/licenses/by-nc-sa/4.0 |