Characterization of galectin-3 expression by immunohistochemistry in mammary intraepithelial lesions in bitches without evidence of tumor
Intraepithelial lesions (IELs) are local morphological abnormalities of the ducts andlobules of the mammary gland that increase the risk of cancer. Programs of earlydetection of breast cancer have improved the identification of IELs. In canines theyhave been proposed as a comparative model with human IELs. Galectin-3 is involved with cancer progression in women and bitches but its role in the biological behaviorof neoplasias is contradictory depending on the source cell. The aim of this study wasto characterize by immunohistochemistry the expression of galectin-3 in 19 mammaryglands (MG) from 6 canines without clinical signs of tumor, containing 50 types of IELsand seven invasive carcinomas, taking into account the percentage of positive cells andthe intensity of color immunoreaction. There wasn’t any immunostaining for galectin-3in the adenosis, in the usual ductal hyperplasias, in the atypical lobular hyperplasia, inthe columnar cell lesions, in the complex carcinomas or in the complex hyperplasias. Apapilloma/adenoma with acinar hyperplasia had multifocal staining in 11-50% of thecells with moderate intensity. Two in situ lobular carcinomas (ISLC) (one of nuclearintermediate grade and the other of high nuclear grade) had 10% staining cells, but theintensity was moderate in one of them and low in the other. Findings suggest that therole of galectin-3 is unimportant in the initiation of IELs, but also that it is a proteinof interest in the progression of the lesions and that it possibly acts in the biologicalbehavior of the disease.
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina Veterinaria y de Zootecnia
2019
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| Online Access: | https://revistas.unal.edu.co/index.php/remevez/article/view/82428 |
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