Can melatonin be a potential “silver bullet” in treating covid-19 patients?
Abstract: The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic.
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Multidisciplinary Digital Publishing Institute
2020
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Subjects: | ENVEJECIMIENTO, VACUNACION, COVID-19, SARS-CoV-2, DIABETES, INFLAMACION, SINDROME METABOLICO, MELATONINA, DETERIORO COGNITIVO, NEURODEGENERACION, ESTRES OXIDATIVO, SISTEMA RENINA-ANGIOTENSINA, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/13665 |
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oai:ucacris:123456789-136652022-03-31T18:54:09Z Can melatonin be a potential “silver bullet” in treating covid-19 patients? Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA Abstract: The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic. 2022-03-22T11:45:06Z 2022-03-22T11:45:06Z 2020 Artículo Cardinali, D.P., Brown, G. M., Pandi Perumal, S. R. Can melatonin be a potential “silver bullet” in treating covid-19 patients? [en línea]. Diseases. 2020, 8 (4). doi: 10.3390/diseases8040044. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13665 2079-9721 https://repositorio.uca.edu.ar/handle/123456789/13665 10.3390/diseases8040044 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Diseases Vol. 8, No. 4, 2020 |
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ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA |
spellingShingle |
ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
description |
Abstract:
The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic. |
format |
Artículo |
topic_facet |
ENVEJECIMIENTO VACUNACION COVID-19 SARS-CoV-2 DIABETES INFLAMACION SINDROME METABOLICO MELATONINA DETERIORO COGNITIVO NEURODEGENERACION ESTRES OXIDATIVO SISTEMA RENINA-ANGIOTENSINA |
author |
Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_facet |
Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_sort |
Cardinali, Daniel Pedro |
title |
Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
title_short |
Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
title_full |
Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
title_fullStr |
Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
title_full_unstemmed |
Can melatonin be a potential “silver bullet” in treating covid-19 patients? |
title_sort |
can melatonin be a potential “silver bullet” in treating covid-19 patients? |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
url |
https://repositorio.uca.edu.ar/handle/123456789/13665 |
work_keys_str_mv |
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